Zebrafish as an Innovative Experimental Model: A Strong Framework for Medical Research in Preclinical Screening | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 136, Volume 29, Issue 4, July and August 2025, Page 2519-2551 PDF (1.11 MB) | ||||
| DOI: 10.21608/ejabf.2025.446041 | ||||
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| Author | ||||
| Kumari et al. | ||||
| Abstract | ||||
| The zebrafish offer numerous advantages over other vertebrate models used in the study of human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, as well as a range of biomedical research applications. Their use in disease modelling is significantly advancing our understanding of the molecular mechanisms underlying human genetic disorders. These efforts are crucial for the development of precision medicine, providing innovative avenues for diagnosis and treatment. This review explores the zebrafish as a model organism, covering its life cycle, habitat management, and applications in biomedical research—with particular emphasis on developmental disorders, mental health conditions, and metabolic diseases. The zebrafish is an exceptionally valuable vertebrate model for both biomedical research and drug development. In particular, the integration of CRISPR-based knockout technology with extensive data from next-generation DNA sequencing is greatly enhancing the efficiency and accuracy of functional validation of Genome-Wide Association Study (GWAS) candidates in the zebrafish. This advancement is pivotal in identifying causative genes and understanding the molecular mechanisms that drive human genetic disorders. Such initiatives are laying the groundwork for the future of precision medicine by offering novel molecular targets for both diagnostic and therapeutic strategies, especially for rare diseases. | ||||
| Keywords | ||||
| Zebrafish; Vertebrate; Applications; Animal model; Biology | ||||
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