Enhancing the Antimicrobial Effect of Ciprofloxacin by Loading with Silica Nanoparticles Derived from Rice Straw: Spectral and Morphological Studies | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 25 August 2025 PDF (1.2 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.387882.2864 | ||
| Authors | ||
| Rania Alwakeel1; Mohamed Moustafa ِِِAbdelaal2; Ola Mohamad El Borady* 3 | ||
| 1Chemistry department, School of Science & Engineering, The American University in Cairo (AUC), Egypt. & Faculty of Biotechnology, October University for Modern Sciences and Arts (MSA University), 6th of October City, Egypt. | ||
| 23Department of Cardiothoracic Surgery, Faculty of Medicine, Kafrelsheikh University, Egypt. | ||
| 3Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, Kafrelsheikh, Egypt | ||
| Abstract | ||
| Antimicrobial resistance is a significant threat to both human and animal health, demanding a One Health approach to therapeutic strategies. The growing resistance of pathogens such as Salmonella, Brucella, E. coli and S. aureus complicates treatment and raises healthcare costs, highlighting the urgent need for alternative therapeutic strategies. Therefore, this study aims to prepare silica nanoparticles (SiO₂-NPs) from rice straw through acid leaching method, then ciprofloxacin, one of the most abundant broad-spectrum antibiotics used worldwide, was loaded to SiO2-NPs. Comprehensive characterization of TEM, SEM, EDX, and FTIR confirmed successful SiO2-NPs synthesis and effective drug incorporation. TEM analysis for unmodified SiO₂-NPs showed spherical particles with a size of 130–170 nm, while ciprofloxacin-loaded SiO₂-NPs (CIP@SiO₂-NPs) expanded to 340–640 nm, indicating successful encapsulation and surface modification. These nanoparticles' antibacterial efficacy was tested against Gram-positive and Gram-negative bacteria frequently involved with zoonotic illnesses. The findings reveal that the ciprofloxacin-loaded SiO₂-NPs exhibit superior antibacterial activity to free ciprofloxacin especially for Gram (+ve) bacterial strains. Furthermore, the study proves the efficacy of rice straw-derived SiO₂-NPs as an eco-friendly nanocarrier approach for improving antibiotic delivery that enhances the management of bacterial infections in veterinary medicine, minimizing the risk of zoonotic disease transmission to humans. | ||
| Keywords | ||
| Antimicrobial resistance; One health approach; Silica Nanoparticles; Rice-Straw; Ciprofloxacin; Zoonotic diseases | ||
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