Inhibition of rabbit brain monoamine oxidase by trans-dichlorotetra (pyridine derivatives) of cobalt (iii) complexes. | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 2, Issue 1, 1990, Pages 91-102 PDF (444.62 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1990.460679 | ||
| Authors | ||
| Nadia Z. Shaban* ; Gehan M. El-Subruiti | ||
| Department of Biochemistry and Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt. | ||
| Abstract | ||
| Rabbit brain monoamine oxidase (MAO) is rapidly inactivated when incubated with trans-Co(3-R-pyridine)4Cl2)Cl since R is methyl (CMPC) or ethyl (CEPC) group. These complexes inhibit MAO enzyme with time dependent and concentration dependent response with I50 value equal to 8.3x10-1 & 3x10-11 M respectively. 8.3x10-10 M from CMPC & CEPC inhibited the MAO enzyme by a noncompetitively inhibition type. The values of Km and Vmax were determined from the Lineweaver-Burk plot. The MAO enzyme is inhibited also by methyl pyridine which is a precursor of these complexes. This inhibition increased by increasing the concentration of methyl pyridine. | ||
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