Interaction of the sesquiterpene-lactones, ambrosin and damsin, and gossypol with insect and snail acetilcholinesterase activity | ||
Journal of Pest Control and Environmental Sciences | ||
Volume 5, Issue 1, June 1993, Pages 77-86 PDF (517.91 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/jpces.1993.460812 | ||
Authors | ||
Samia A. B. Abo-seda1; Mahmoud M. Abo El-Saad* 2 | ||
1Plant Protection Research Institute, Agric. Res. Centre, CAPL, Bacous, Alex., Egypt. | ||
2Pesticide Chemistry Dept., Faculty of Agriculture, Alexandria University. | ||
Abstract | ||
The two sesquiterpene-lactones, ambrosin and damsin which are the major components in the ethanol extract of Damssissa plant of (Ambrosia meritima) and gossypol (sesquiterpene) naturally exist in cotton plant were tested against of AChE activity , The enzyme was prepared from house flies Musca domestica as well as Theba pisana (Muler) a terrestrial snails. The effects of the three compounds on the enzyme from both sources were varied. So that whereas gossypol stimulate the enzyme activity from both sources, the two sesquiterpene-lactones extracted from damssissa inhibited the enzyme activity from house flies. However, the susceptibility of the enzyme activity from snails towards the two sesquiterpene-lactones were different. So, although ambrosin still inhibit the enzyme activity from this source as well as the house flies, dams in showed a stimulatory effect similar to that of gossypol. On the other hand, although ambrosin inhibited the activity of the enzyme from both sources *kinetic analysis of the inhibition showed different inhibition mechanisms of the both cases. The results were discussed in terms of the chemical structure of the three compounds tested and o t the possible variation of the enzyme from the two sources used in the study. | ||
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