Changes in blood chemistry of albino mice due to induced intoxication with the organophosphorus pesticide cyanophos | ||
| Journal of Pest Control and Environmental Sciences | ||
| Volume 4, Issue 2, December 1992, Pages 135-150 PDF (7.65 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpces.1992.462284 | ||
| Authors | ||
| Amal A. Eisa* ; Mohamed F. F. Bayomy | ||
| Plant protection Dept., Fac. of Agric. and Zoology Dept. Fac. of Sci. Menofia Univ. | ||
| Abstract | ||
| The present study examines the toxic effects of single as well as repeated sublethal doses of (animals' were the organophosphate, cyanophos value 1/4 LD.. injected intraperitoneally with 2, or 4 days) on male adult once daily over 1. albino mice (Mus musculus). Animals received the single dose were decapitated at 24, 48, 96 and exposure, while those treated 192 hrs post repeatedly were sacrificed at 24 hrs after the last injection. Results indicate the occurrence of subtle cases of decline in serum albumin in both treatment whereas both globulins and total exhibited proteins escalation, particularly during the follow-up period for the single dose. Also, this effect vigorously potentiated by the duration of administration. elongating in a severe alteration resulted foregoing of the albumin/globulin (A/G) ratio disturbance where it underwent highly significant decrease in almost all treated groups as compared with their respective controls. Elevation in aminotransferase activity of enzymes (GPT and GOT) has occurred especially after dosage, whereas alkaline phosphatase was inhibited markedly under the same conditions. This study suggests that the severity of the toxic effect of repeated exposure is duration dependent whereas the toxic action of the single days within 8 dose is relatively reduced post-treatment. | ||
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