COMPARISON BETWEEN THE EFFECT OF MEBO AND ENDOFORM PATCHES TO REPAIR INDUCED SKIN WOUNDS IN DOGS | ||
| Assiut Veterinary Medical Journal | ||
| Article 46, Volume 71, Issue 187, October 2025, Pages 585-604 PDF (1.15 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.374394.1666 | ||
| Authors | ||
| RADHWAN RYAD AL-AJELI; AHMED SAAD AL-QADHI; S.M. IBRAHIM* ; O. H. AL-HYANI | ||
| Department of Surgery and Theriogenology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| This study aimed to compare the ability of mebo and endoform patches for restoring full-thickness cutaneous wounds in dogs. Twenty-seven local strain mature dogs were used. For all experimental animals, a 2x2 cm of square full-thickness skin defects were carried out on the lateral side of the radial area. Then, these animals were divided into three identical groups. In first group (control), these induced defects were left open to heal spontaneously without any kind of remedy, while for the 2nd and 3rd groups, mebo and endoform patches of the same defect dimensions were placed over the wounds and bandaged firmly. The evaluation of the outcome data was done at 7th, 14th and 21th days postoperatively according to the gross and histopathological examinations. The gross results exhibited that the start and progress of the healing process was much faster and better in both mebo and endoform groups since first week, compared to the control group, however, Endoform animals were even better. Furthermore, there was a gradual reduction in wound size of both treated groups, especially of Endoform, compared to the control group. Furthermore, the histopathological evaluation displayed extra and more mature granulation tissue formation with little or tiny inflammatory cell infiltration, good angiogenesis, re-epithelization and development of hair follicle and other skin appendage in both treated groups, compared to the control group. In conclusion, similarly mebo and endoform patches can be considered for hastening perfect healing of cutaneous full-thickness wounds in dogs, even though endoform is regraded the first top choice. | ||
| Keywords | ||
| Cutaneous Wounds; Mebo Patch; Endoform; Healing Process; Extracellular Matrix | ||
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