Evaluation of CD68 and MCP1 in Patients with Bacterial Prostatitis | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (434.8 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.428815.1904 | ||
| Authors | ||
| Zahraa D. Gheni* 1; Israa S. Abbas2 | ||
| 1Department of Medical Microbiology, College of Applied Medical Sciences, University of Kerbala, Karbala, Iraq | ||
| 2College of Al-Amal Specialized Medical Sciences, Karbala/Iraq | ||
| Abstract | ||
| Background: Bacterial prostatitis is a medical condition that affects the prostate gland. It is considered one of the most common urinary tract infections in males. There are two types of this condition: acute and chronic. Both types present with urinary symptoms and pelvic pain, but they differ in severity and duration.CD68 is a marker on the surface of macrophages that significantly contributes to immune response recognition, while MCP-1 chemokine attracts monocytes to the site of inflammation. The elevated levels of both immunological biomarkers in the blood, along with other inflammatory markers that are widely linked to the immune response. Aim of Study: This study investigates the evaluation of immune and inflammatory markers in patients with bacterial prostatitis. Methodology: A case-control study was conducted at a private clinic in Karbala and at Al-Nassiriya Teaching Hospital in Al-Nassiriya city from October 2024 to May 2025. The study involved 120 male participants, divided into three groups: Eighty patients diagnosed with acute and chronic bacterial prostatitis, and forty healthy men with no prior history of prostate infections. The participants' ages ranged from 34 to 74 years; all men were diagnosed by a urologist based on patient history and NIH criteria.MCP-1 and CD68 have been measured in men by the ELISA technique. Results: Patients with ABP and CBP exhibited significantly higher levels of WBC, CRP, and PSA compared to the control group (p < 0.01). Immune markers CD68 and MCP-1 were effective in distinguishing between ABP and CBP infections (p < 0.01). ROC analysis showed that, in ABP, MCP-1 had the highest diagnostic accuracy with an AUC: 99.375%), followed by CD68 (AUC: 99.063%) and PSA (AUC: 96.906%). In CBP, MCP-1 also demonstrated superior performance (AUC: 99.219%), outperforming CD68 and PSA (AUCs: 92.906% and 95.094%, respectively). Conclusion: In both acute and chronic prostatitis, significantly elevated levels of MCP-1 and CD68 were observed, clearly reflecting the presence of inflammatory activity in prostate tissue. Furthermore, both MCP-1 and CD68 demonstrated high sensitivity and specificity compared to PSA, thereby enhancing their diagnostic accuracy. | ||
| Keywords | ||
| Prostatitis; CD68; MCP-1; PSA; CRP | ||
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