Experimental Trail for Controlling Ochratoxicosis in Poultry Using Nano Titanium Dioxide | ||
| Egyptian Journal of Veterinary Sciences | ||
| Volume 56, Issue 13, December 2025, Pages 1047-1060 PDF (1.02 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.419299.3092 | ||
| Authors | ||
| Safaa M. Elmesalamy1; Nermin f. El zohairy1; Sara A. Abdelwahab2; Sahar s. Abdelhamied3; Reham A.A. Mahmoud* 4; Rasha M.H. Sayed-ElAhl5; Mogeda K. Mansour4 | ||
| 1Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Zagazig branch, Egypt. | ||
| 2Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Zagazig branch, Egypt | ||
| 3Department of Clinical Pathology, Animal Health Research Institute (AHRI), Agriculture Research Center, Zagazig Branch, Zagazig 44516, Egypt | ||
| 4Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki branch, Egypt | ||
| 5Department of Mycology and Mycotoxins, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Dokki, Giza, Egypt | ||
| Abstract | ||
| The mycotoxin ochratoxin A (OTA) poses the risks of nephrotoxicity, hepatotoxicity, teratogenicity and immunotoxicity in animals. Nanoparticles from different minerals are often incorporated into chicken feed to serve as an alternative to antibiotics, promote growth, development, and a robust immune system. This research investigated the effects of 30 ppb of dietary OTA on broiler chickens' growth, blood indicators, biochemical measures, and oxidative stress, and the ability of nano-titanium dioxide (TiO2) to counteract its effect. Fifty one-day-old Cobb broiler chicks were divided into five groups each group containing 10 chicks: Gp1: control group, Gp2: fed diet containing 30 ppb of OTA Gp3: fed diet containing 30 ppb OTA plus 20% of nano-titanium dioxide (TiO2), Gp4: fed diet containing 30 ppb OTA plus 40% of TiO2 , and Gp5: fed diet containing 30 ppb OTA plus 80% TiO2 . Our results showed significant decrease in body weight gain, Hb concentration, PCV%, WBCs, heterophiles and lymphocytic count. Levels of pro-inflammatory cytokines, malondialdehyde, catalase, and nitric oxide , liver and kidney serum enzyme activity, reduced glutathione and total antioxidant capacity of OTA intoxicated broiler.increased significantly. Chickens in non-treated groups that received ochratoxin only had noticeable levels of ochratoxin residues in the liver and muscle tissues. However, TiO2 NPs addition to diet improved all the previous parameters. In conclusion, nano-titanium dioxide (especially with a concentration of 40 %) minimized the harmful effects of OTA in broilers and improved its elimination from liver and muscle tissues. | ||
| Keywords | ||
| Nano titanium dioxide; poultry; Electrophoresis; hematology; ochratoxin-A residue | ||
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