INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS | ||||
| Kafrelsheikh Veterinary Medical Journal | ||||
| Article 5, Volume 11, Issue 1, April 2013, Page 79-90 PDF (584.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/kvmj.2013.110166 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ayman Atiba* 1; Walied Abdo2; Fedekar F. Madkour3 | ||||
| 1Departments of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt. | ||||
| 2Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt. | ||||
| 3Marine Science Department, Faculty of Science, Port Said University, Egypt. | ||||
| Abstract | ||||
| Objectives:To investigate the feasibility and safety of brown algae (Cystoseira myrica) extract in the improvement of wound healing process. Materials and Method:Full thickness excision wounds (1.5 x 1.5 cm) were created under general anesthesia on the back of the rats. These rats were divided into two groups; control group (Group C) and brown algae extract topical application group (Group B). Each wound area was measured on days 0, 3, 6, 9, 12, 15 and 18 post-wounding. On day 18 post-wounding, animals were sacrificed. Quantification of granulation tissue and their biochemical and histological aspects in control as well as treated groups were estimated. Results: Brown algae extract showed significant increase in wound contraction and formation of scars on days 9, 12, 15 and18 post wounding (p < 0.001). Histologically, extracellular matrix deposition and epithelialization were promoted in Group B. Conclusion: The present results suggest that brown algae (Cystoseira myrica) extract can effectively improve wound healing in a full-thickness skin wound model. Use of brown algae (Cystoseira myrica) extract might therefore facilitate development and improvement of wound healing treatments in future. | ||||
| Keywords | ||||
| Brown algae; Cystoseira myrica; Skin; Wound healing | ||||
|
Statistics Article View: 170 PDF Download: 215 |
||||
