Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma
Abozaid, O., Moawed, F., Salah Kawara, R. (2018). Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma. EKB Journal Management System, 35(2), 537-546. doi: 10.21608/bvmj.2018.111625
Omayma Abozaid; Fatma Moawed; Ragaa Salah Kawara. "Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma". EKB Journal Management System, 35, 2, 2018, 537-546. doi: 10.21608/bvmj.2018.111625
Abozaid, O., Moawed, F., Salah Kawara, R. (2018). 'Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma', EKB Journal Management System, 35(2), pp. 537-546. doi: 10.21608/bvmj.2018.111625
Abozaid, O., Moawed, F., Salah Kawara, R. Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma. EKB Journal Management System, 2018; 35(2): 537-546. doi: 10.21608/bvmj.2018.111625

Protective effect of benzethonium chloride on diethylnitrosamine-induced hepatocellular carcinoma

Benha Veterinary Medical Journal
Article 45, Volume 35, Issue 2, December 2018, Page 537-546  XML PDF (331.5 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2018.111625
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Authors
Omayma Abozaid1; Fatma Moawed2; Ragaa Salah Kawara1
1Faculty of Veterinary Medicine, Benha University
2Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt
Abstract
This study aims to evaluate the protective effect of Benzethonium Chloride (BZC) on- diethylnitrosamine (DEN)‑induced hepatocellular carcinoma. Thirty-two male albino rats were used (eight animal per group). The hepatocarcinogenesis was induced in male Wistar albino rats by DEN (20 mg/kg b.w, orally (five times per week for 6 weeks). The treatment group rats received a similar dosage as above then injected with benzethonium chloride (5 mg/ kg b.w i.p.) for 4 weeks. Blood samples for serum parameters were collected or determination of  biochemical markers such as alanine amino transaminase (ALT), aspartate amino transaminase (AST), alkaline phosphatase (ALP), and total bilirubin, albumin and total protein. Also, liver tissues were taken for histopathological investigation. The obtained result revealed that treatment with benzethonium chloride significantly reduced DEN-induced elevation of ALT, AST and ALP activities and total bilirubin concentration. However, significant increase in the serum albumin and total protein concentration were observed in benzethonium chloride-treated rats as compared with DEN‑treated  group. The obtained results suggest that  benzethonium chloride possesses chemopreventive activity against DEN‑induced liver cancer.
 
Keywords
Diethylnitrosamine; Benzethonium Chloride; Hepatocellular carcinoma; Liver marker enzymes
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