Side effects of dexibuprofen have been ameliorated with vitamin E | ||||
| Benha Veterinary Medical Journal | ||||
| Article 41, Volume 36, Issue 1, March 2019, Page 382-392 PDF (500.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2019.114267 | ||||
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| Authors | ||||
| Gamal El-Din Shams; Suhair Abd El-Latif; Haydi Abdallah | ||||
| Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| The present study was designed to define the effects of daily administration of 100 mg vitamin E\kg on side effects in mice treated with dexibuprofen (7.2 mg/kg, P.O once daily) for 21 consecutive days and its antioxidant scavenging capacity. Blood samples were collected from mice on 1st, 2nd, 14th, 21st days post –treatment and tissue samples were collected on 7th, 14th days post-treatment to assess the protective effects of vitamin E. The results indicated significant increase in antioxidant enzymes Glutathione peroxidase, dismutase superoxide dismutase(SOD)&catalase (CAT) together decrease the level of malondialdehyde besides diminished and in portal fibrosis and decrease in congestion of hepatic blood vessels and sinusoids caused by dexibuprofen administration as demonstrated by kidney histopathology Therefore, Vitamin E should be taken with dexibuprofen to decrease its side effects. | ||||
| Keywords | ||||
| Antioxidant activity; Dexibuprofen; Histopathology; Vitamin E | ||||
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