DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL [1,2,4]TRIAZOLO[4,3-A] QUINOXALINONES | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 15, Volume 52, Issue 2 - Serial Number 52, September 2015, Page 208-218 PDF (510.98 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2015.12554 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Adel Ghiaty | ||||
| Al-Azhar University, Faculty of Pharmacy, Organic Chemistry Department, Cairo 11884, Egypt | ||||
| Abstract | ||||
| A series of novel [1,2,4]triazolo[4,3-a]quinoxalinone derivatives have been synthesized. The structures of the newly synthesized compounds were confirmed by elemental analysis and different spectral techniques. The in vitro antimicrobial screening of some selected compounds was carried out using the diffusion agar technique. Compound 14c was found to be the most active antibacterial agent against Escherichia coli using gentamicin as reference drug. All the tested compounds showed no activity against Candida albicans and Pseudomonas aerugeosa. | ||||
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