Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery
El-Garhy, E., Mohamed, A., Elshahat, A., Abu Elmagd, I., Hamed, M. (2018). Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery. EKB Journal Management System, 73(2), 6157-6164. doi: 10.21608/ejhm.2018.12737
Esmail Talaat El-Garhy; Ashraf Hamdy Mohamed; Ashraf Elshahat; Ibrahim Abu Elmagd; Mohamed Awad Allah Hamed. "Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery". EKB Journal Management System, 73, 2, 2018, 6157-6164. doi: 10.21608/ejhm.2018.12737
El-Garhy, E., Mohamed, A., Elshahat, A., Abu Elmagd, I., Hamed, M. (2018). 'Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery', EKB Journal Management System, 73(2), pp. 6157-6164. doi: 10.21608/ejhm.2018.12737
El-Garhy, E., Mohamed, A., Elshahat, A., Abu Elmagd, I., Hamed, M. Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery. EKB Journal Management System, 2018; 73(2): 6157-6164. doi: 10.21608/ejhm.2018.12737

Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery

The Egyptian Journal of Hospital Medicine
Article 28, Volume 73, Issue 2, October 2018, Page 6157-6164  XML PDF (333.65 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.12737
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Authors
Esmail Talaat El-Garhy1; Ashraf Hamdy Mohamed1; Ashraf Elshahat1; Ibrahim Abu Elmagd2; Mohamed Awad Allah Hamed email 2
1Department of Obstetrics and Gynaecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Department of Obstetrics and Gynaecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Abstract
Objective: To assess the efficacy of tranexamic acid in reduction of blood loss and pervention of postpartum hemorrhage after vaginal delivary. Methods: This is a multicentric prospective randomized double blind placebo controlled trial. 200 pregnant women were randomized to receive either 60 mg/kg of tranexamic acid (TA) (n=100) or placebo (n=100) intravenously in the second stage of labour. Postpartum blood loss was collected and measured accurately from placental delivery to 2 hours postpartum and adverse effects of were observed. Results: The mean estimated postpartum blood loss was significantly lower in women treated with tranexamic acid compared to women in the placebo group    ( 442.50 ± 128.55 versus 555.75 ± 191.88, respectively; p < 0.001), and the proportion of women in the tranexamic acid group who had an estimated blood loss  ≥ 500 mL was significantly lower than in the placebo group( 3 [3 %] versus 9 [9%],relative risk [RR]=0.30; 97% confidence interval [CI] 0.11 to 0.78;P<0.05). Maternal and neonatal outcomes did not differ significantly between both groups. Conclusion: The addition of tranexamic acid to the active management of third stage of labor after normal vaginal delivery is effective as a prophylaxis against post-partum hemorrhage. It can significantly reduce blood loss during and after delivery.
 
Keywords
Tranexamic acid; postpartum haemorrhage; blood loss
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