A Randomized-Trial Study of Corneal Collagen Cross-Linking (CXL) in Progressive-Keratoconus (PK) | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 13, Volume 81, Issue 6, October 2020, Page 2179-2183 PDF (398.77 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2020.127965 | ||||
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| Author | ||||
Hassan Shamselden Yousef 
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| Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt | ||||
| Abstract | ||||
| Background: Keratoconus is a frequent, familiar, bilateral, non inflammatory, and gradually progressive corneal ectasia, which leads to corneal protrusion, irregular astigmatism, and decrease vision. Currently, the corneal cross-linking (CXL) treatment could attain vision improvement. Aim: To investigate the topographic, refractive, and clinical-out-comes after six months CXL in gradually progressing keratoconic eyes. Patients & Methods: A follow-up, randomized, controlled-trial study was used. In this study, 30eyes with progressive- keratoconus (PK) were recruited in the study. Cross-linking was done and achieved by a solution of 0.1% riboflavin mixture with 20% dextran for 15minutes before and during 30minutes time-period of ultraviolet A (UV-A) irradiation (3Mw\cm2). The obtained data were analysed using IBM SPSS software. Results: Statistically significant improvements were noticed in Sim k (at 6months), Kmin (at 6months), spherical power (at 6momths), cylinder power (at 6momths), spherical equivalent [SE] (at 6months), uncorrected visual acuity (UCVA) (at 6months) and best corrected visual acuity [BCVA] (at 6months) in trial group (15patients) when compared with the controls. Conclusions: At 6months, hopeful, promising improvements were reported in Kmax, UCVA, and BCVA. So, long term studies are requested to survey the efficiency of CXL as well as the safety of the repeated procedures. | ||||
| Keywords | ||||
| Corneal collagen cross-linking; Riboflavin; Epithelium-off procedure; Topographics changes; Keratoconus | ||||
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