Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction
Mohammed, W., Hassan, S., ALahmady, H., Shawkat, W., Abd Elazeem, A., ELsharabasy, I., Nazif, I. (2021). Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction. EKB Journal Management System, 8(1-B), 109-115. doi: 10.21608/adjg.2021.23389.1237
Wafaa A. Mohammed; Suzan A. Hassan; Hatem H. ALahmady; Wael M. Shawkat; Ahmad F. Abd Elazeem; Ibrahim M. ELsharabasy; Ismail O. Nazif. "Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction". EKB Journal Management System, 8, 1-B, 2021, 109-115. doi: 10.21608/adjg.2021.23389.1237
Mohammed, W., Hassan, S., ALahmady, H., Shawkat, W., Abd Elazeem, A., ELsharabasy, I., Nazif, I. (2021). 'Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction', EKB Journal Management System, 8(1-B), pp. 109-115. doi: 10.21608/adjg.2021.23389.1237
Mohammed, W., Hassan, S., ALahmady, H., Shawkat, W., Abd Elazeem, A., ELsharabasy, I., Nazif, I. Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction. EKB Journal Management System, 2021; 8(1-B): 109-115. doi: 10.21608/adjg.2021.23389.1237

Evaluation of 3D Printed Computer Assisted Patient’s Specific Scaffold Seeded by Autologous Bone Marrow Mononuclear Cells in Mandibular Reconstruction

Al-Azhar Dental Journal for Girls
Article 14, Volume 8, 1-B, January 2021, Page 109-115  XML PDF (394.29 K)
Document Type: Original Article
DOI: 10.21608/adjg.2021.23389.1237
View on SCiNiTO View on SCiNiTO
Authors
Wafaa A. Mohammed email 1; Suzan A. Hassan2; Hatem H. ALahmady3; Wael M. Shawkat4; Ahmad F. Abd Elazeem5; Ibrahim M. ELsharabasy6; Ismail O. Nazif7
1Demonstrator of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
2Professor of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
3Professor of Oral and Maxillofacial Surgery and Head of Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
4Head of Oral and Maxillofacial Surgery Department, Health insurance hospital, Cairo, Egypt.
5Assistant researcher of regenerative medicine and genetics, Oro-dental Genetics Department, Human Genetics Division, National Research Center, Cairo, Egypt.
6Consultant of Oral and Craniomaxillofacial Surgery.
7Electrical and Medical 3D Printing Engineer.
Abstract
Purpose: This study was carried out to evaluate both clinically and radiographicly the use of 3D printed computer assisted patient’s specific scaffold seeded with ABMMCs in mandibular reconstruction. Materials and methods: The present study was conducted on eight patients who needed mandibular reconstruction. All patients in this study were subjected to mandibular reconstruction using 3D printed computer assisted patients specific scaffold using PLLA scaffold seeded with ABMMCs combined with osteoplastic materials of biological origin as Osteomatrix (LLC Konectbiopharm, Russia) which composed of natural collagen and hydroxyapatite with affinity-bound sulfated glycosaminoglycan (SGAG). All patients underwent preoperative cranial-maxillofacial CT scans, immediate postoperative and after six months for assessment of bone density and volume changes. Results: The reduction in bone density (17.4%) and bone volume (14.5%) from immediate to six months was statistically significant. There was an increase in bone density in the area near the autogenous bone of the patient than the area far from the autogenous bone of the patient. Conclusion: Using 3D printed computer assisted patient’s specific scaffold seeded with ABMMCs combined with Osteoplastic materials of biological origin in mandibular reconstruction is useful in small defects.
Keywords
Mandibular reconstruction; Poly (L-lactide) lactic acid; 3D printed
Statistics
Article View: 221
PDF Download: 220