Histopathological changes of kidney tissue during aging | ||||
| SVU-International Journal of Veterinary Sciences | ||||
| Article 6, Volume 4, Issue 1 - Serial Number 7, March 2021, Page 54-65 PDF (1.03 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/svu.2021.55868.1092 | ||||
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| Authors | ||||
Mohamed Hosny Abdelhafez Kotob  1; Ahmed Hussein2; Mahmoud Abd-Elkareem3
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| 1Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. | ||||
| 2Zoology Department, Faculty of Science, Al-Azhar University, Assiut, Egypt | ||||
| 3Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Kidney aging is a normal physiological process associates with various molecular, morphologic and functional changes in the kidney tissues. This work was designed to study microscopically the structural changes in the kidney tissue of aged rats compared to young rats. Male Sprague–Dawley rats were used 10 young rats (4 months) and 10 aged rats (24 months). Rats were transcardially perfused with 4% paraformaldehyde. The kidneys were post fixed for 24 hours in 4 % PFA then proceeded for normal histopathology and light microscopic examination. Kidney tissue of aged rats showed serious morphological changes such as; segmental glomerulosclerosis, pericapsular fibrosis, tubulointerstitial fibrosis, perivascular fibrosis, inflammatory cell infiltration, tubular dilatation, intra-tubular cast formation and tubular atrophy. These changes were compared to the normal histological appearance of glomeruli, tubules, interstitium, blood vessels of young rat kidneys. In addition, the kidney tissue of the aged rats showed compensatory glomerular hypertrophy, tubular hyperplasia and endothelial proliferation. Renal aging involves several degenerative changes in kidney structure and these alterations interfere with the physiologic functions and end with chronic renal failure. | ||||
| Keywords | ||||
| Aging; Kidney; Glomerulosclerosis; Tubulointerstitial fibrosis; rats | ||||
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