Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study)
Omar, N. (2012). Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study). EKB Journal Management System, 48(1), 357-367. doi: 10.21608/ejhm.2012.16240
Nahed Ahmed Omar. "Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study)". EKB Journal Management System, 48, 1, 2012, 357-367. doi: 10.21608/ejhm.2012.16240
Omar, N. (2012). 'Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study)', EKB Journal Management System, 48(1), pp. 357-367. doi: 10.21608/ejhm.2012.16240
Omar, N. Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study). EKB Journal Management System, 2012; 48(1): 357-367. doi: 10.21608/ejhm.2012.16240

Effect Of Some Aflatoxins On A Lymphatic Organ (Spleen) Of Male Albino Rats (Histopathological Study)

The Egyptian Journal of Hospital Medicine
Article 3, Volume 48, Issue 1, July 2012, Page 357-367  XML PDF (2.15 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2012.16240
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Author
Nahed Ahmed Omar
Department of Zoology, Faculty of Science, Damietta Branch, Mansoura University.
Abstract
 Background:The present study was planned to compare between two kinds of aflatoxins ( AFB2 and AF Mix) on spleen of male albino rats. Fifty young male albino rats ,each weighing 50g, were fed on diets containing aflatoxins at concentration of 1.0 ppm either of AFB2 or AF mix. for 2, 4, 6 weeks followed by a withdrawal period of 2 weeks.
 
Material and Methods:- Rats were randomly divided into 3 groups: the 1st group of 10 rats was fed on the standard diet. The 2nd and the 3rd groups of 20 rats each were maintained on the standard diet plus either AFB2 or AF mix. respectively. Ten animals from the latter 2 groups as withdrawal period. Pieces of spleen were subjected to histological procedures and the obtained sections (6 µm thick) were stained with the haematoxylin and eosin, also, mercuric bromophenol blue stain for total protein were used in this study.
 
Results:-  Marked histopathological alterations were observed in the studied sections under the influence of AFB2 and AF mix. It was found that AFB2 induced more alterations. The most common changes were lymphocytic degeneration, fatty changes with numerous hemorrhagic areas.
The two weeks withdrawal period showed a partial recovery of the developed changes.
 
Conclusion:-  This study indicated that AFB2 has a toxic effect on spleen than the equivalent level of AF mix.  .Great caution must be followed to prevent the possible contamination of our food with such mycotoxins.
 
Keywords
Aflatoxins – Spleen – Histopathology
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