Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera
Soliman, N., El-Desouky, M., Nahas, A. (2021). Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera. EKB Journal Management System, 64(10), 5585-5595. doi: 10.21608/ejchem.2021.73925.3658
Noha Ibrahim Soliman; Mohamed El-Desouky; Abd El-Hamid Abd El-Meged Nahas. "Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera". EKB Journal Management System, 64, 10, 2021, 5585-5595. doi: 10.21608/ejchem.2021.73925.3658
Soliman, N., El-Desouky, M., Nahas, A. (2021). 'Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera', EKB Journal Management System, 64(10), pp. 5585-5595. doi: 10.21608/ejchem.2021.73925.3658
Soliman, N., El-Desouky, M., Nahas, A. Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera. EKB Journal Management System, 2021; 64(10): 5585-5595. doi: 10.21608/ejchem.2021.73925.3658

Cypermethrin-Induced Lung Damage in Albino Rats: The Preventive Impact of Moringa oleifera

Egyptian Journal of Chemistry
Article 19, Volume 64, Issue 10, October 2021, Page 5585-5595  XML PDF (427.64 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.73925.3658
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Authors
Noha Ibrahim Soliman1; Mohamed El-Desouky email orcid 1; Abd El-Hamid Abd El-Meged Nahas2
1Biochemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
2Mammalian Toxicology Department, Central Agriculture Pesticides Lab, Agricultural Research Center, Dokki, Giza 12618, Egypt
Abstract
Cypermethrin (CYP) is a popular environmental toxicant because of its wide-ranging use as a broad-band insecticide. The purpose of this research was to explore the potential impact of Moringa oleifera leaves extract (MOLE) as a protective agent against cypermethrin-induced lung toxicity in male albino rats. Forty experimental animals were allocated into four groups. G1 served as the negative control, G2, G3 and G4 were orally treated with MOLE (250 mg/kg body weight), CYP (26.15mg/kg body weight) and CYP + MOLE, respectively. CYP oral administration for 28 days elevated the levels of oxidative stress biomarkers like Malondialdehyde, superoxide dismutase, catalase and glutathione S-transferase and caused a decline in the content of reduced glutathione in the lung tissue of the rats. Lung injury was verified by histopathological changes evidenced by interstitial pneumonia, marked perivasculitis, focal pulmonary hemorrhage, haemosidrosis and pulmonary edema in CYP-exposed rats. Co-administration of MOLE mitigated the induced oxidative stress and histopathological alterations. As a result, Moringa oleifera can prevent cypermethrin-induced lung toxicity due to its free radical scavenging and antioxidant properties.
Keywords
Pyrethroid; Cypermethrin; Moringa oleifera; Lung; Oxidative stress; Histopathology
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