4N Donor Atoms Moiety of Transition Metal Complexes of a Schiff base Ligand: Synthesis, Characterization and Biological Activities Study | ||||
Egyptian Journal of Chemistry | ||||
Article 57, Volume 64, Issue 10, October 2021, Page 5975-5987 PDF (654.85 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2021.71668.3575 | ||||
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Authors | ||||
sabreen mohamed el-gamasy 1; samar Ebrahim 2 | ||||
1chemistry department, faculty of science, menuofia university | ||||
2Clinical Pathology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt. | ||||
Abstract | ||||
Prepared new Schiff base ligand [H2L] with 4N donor atoms moiety by reacting amine derivative of o-phenylenediamine hydrazide moiety with benzaldehyde. Co(II), Ni(II), Cu(II) and Zn(II) of the new Schiff base were prepared by using a molar ratio of ligand: metal as (1:1). The structure of the Schiff base and the prepared complex was determined by 1H NMR, UV–Vis, IR, Mass spectrometry and molar conductivity. The thermal stability of the complexes had been studied by TGA. The spectral statement displays that the ligand behaves as bidentate ligand. On the basis of the spectral studies, reveal that an octahedral geometry had been assigned for all complexes. The Anti-proliferative effect was screened against human hepatocellular liver carcinoma cell line (HepG2) and antimicrobial activity had been inspected. Result points that complexes demonstrate the increase cytotoxicity in proliferation to cell lines as compared to free ligand. | ||||
Keywords | ||||
complexes; spectral analyses; antimicrobial; anti-proliferative | ||||
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