Eco-Friendly Method for Determination of Allopurinol Drug in pure form and Pharmaceuticals after Cloud Point Extraction | ||||
| Egyptian Journal of Chemistry | ||||
| Article 10, Volume 64, Issue 10, October 2021, Page 5503-5510 PDF (634.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.78208.3821 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maha Al-Tameemi1; Sadeem Subhi Abed2; Esraa Amer Kadhim1; Noor J. Mohammed1; Saadiyah A. Dhahir1 | ||||
| 1Department of chemistry, College of science for women, University of Baghdad | ||||
| 2Department of chemistry, College of science , University of Baghdad | ||||
| Abstract | ||||
| A new spectrophotometric method for the determination of allopurinol drug was investigated. The proposed method was based on the determination of allopurinol in pharmaceuticals. The method relies on the interaction of metal ions with allopurinol in an alkaline medium to form a micelles extracted from a non-ionic surfactant (Triton X-114) and allopurinol-Ag II at a maximum of 906 nm. Experimental variables were performed individually to obtain high extraction efficiency for both compounds. Under optimal conditions, Beer’s law was obeyed in the concentration range of 5-35 μg ml-1 ( r=0.9997) the detection limits of 0.245951 μgml-1 The proposed method was applied successfully for the determination of allopurinol drug in pharmaceuticals with a good accuracy and precision. The optimum condition for the colour development has also been investigated. | ||||
| Keywords | ||||
| drug; allopurinol; silver Cloud Point Extraction; chelating complex | ||||
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