EXPERIMENTAL STUDY FOR EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE AQUEOUS GARLIC EXTRACT IN TREATMENT OF ARTHRITIS IN RABBITS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 19, Volume 57, Issue 131 - Serial Number 4, October 2011, Page 1-18 PDF (561.4 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2011.176922 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| MOHAMMAD A. AL-TALIBI | ||||
| Dept. of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||||
| Abstract | ||||
| The study was conducted to evaluate the ability of Aqueous Garlic Extract (AGE) for inhibition the growth of Salmonella typhimurium as a probable cause of arthritis in rabbits in vitro and in vivo study. Results revealed that AGE (contain 201.2µg/ml allicin) have excellent antibacterial activity against this strain at ≥60% concentration, while the concentration ≥20% showed moderate activity, M oreover concentration of <20% show no effect in vitro. The in vivo study was explained the infectious dose of Salmonella typhimurium that induce arthritis in experimental animals was ≥ 1×105 C.F.U/ml when injected intrarticularly. Garlic extract was administrated to treat experimental induced arthritis for 5 days by using different doses subcutaneously. It have been shown that a dose rate of 100mg/kg B.W S.C were more effective and have no adverse effects. Some bacteriology, serology and hematological tests were used as indicators to confirm infection and evaluation of treatment in rabbits. | ||||
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