Non-fasting Non-High Density Lipoprotein Cholesterol (Non-HDL-C) AS A predictor of Atherosclerosis in Patients with End Stage Renal Disease on Regular Hemodialysis | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 3, Volume 24, Issue 1, July 2006, Page 430-441 PDF (654.74 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2006.17907 | ||||
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Authors | ||||
Sabry Gohar1; Mone Hosny1; Howayda Abdel-Hamid1; Yasser Ibrahim2 | ||||
1Internal Medicine Department, Ain Shams University | ||||
2Damanhour Medical Institute | ||||
Abstract | ||||
Fiftypatientswithchronicrenalfailureonregularhemodialysis31malesand19females, agedfrom18to62yearswereincludedinthestudy.Theywereselectedfromthoseattending theNephrologyandDialysisUnitinDamanhourMedicalInstitute. Tenageandsexmatchedsubjectswithnormalrenalfunctionservedascontrolgroup.Full historytaking,clinicalexamination,restingECGandserumcholesterol,HDL(non-fasting), fastingLDL,non-fastingnon-HDLfromspecialequation,Non-HDL=totalcholesterol-HDL andDuplexscanningofbothcarotidandfemoralarteries. Nonfastingnon-HDLwasmorethan130mg/dlinmorethan65%ofpatientsgroup versus30%incontrolgroup,serumlevelofnon-fastingcholesterolandnon-fastingnon-HDL weresignificantlyelevatedinhemodialysispatientsascomparedwithcontrolgroup,while serumlevelofnon-fastingHDLandfastingLDLweresignificantlydecreasedinhemodialysis patientsascomparedwithcontrolgroup.Intima-Mediathickness(IMT)ofbothcarotidsand bothfemoralarterieswaselevatedinhemodialysispatientsascomparedwithcontrolgroup. Therewasasignificantpositivecorrelationbetweennon-fastingnon-HDLandIMTofboth carotidsandbothfemoralarteriesandasignificantpositivecorrelationbetweenfastingLDL andIMTofbothcarotidsandfemoralarteries.Therewasasignificantpositivecorrelation betweendurationofdialysisandIMTofbothcarotidsandleftfemoralarteries. ApositivecorrelationexistsbetweenECGischemicchangesandIMTofbothcarotidsand leftfemoralarteriesandbetweencarotidplaquesandIMTofbothcarotidsandleftfemoral arteries. Aim of the Work Tostudyandcomparebetweenthelevelofnon-fastingnon-HDL-CandfastingLDLin predialysisserumaspredictorofatheroscleroticchangesinpatientswithendstagerenaldisease onregularhemodialysis. | ||||
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