Angiotensin Converting Enzyme Gene Polymorphism in Egyptian Patients with Systemic Lupus Erythematosus | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 11, Volume 21, Issue 1, October 2005, Page 131-138 PDF (247.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2005.18055 | ||||
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| Authors | ||||
| El-Shafeey M.M; El-Shayeb M; Othman E; Elfawy N | ||||
| Allergy and Immunology Department of Internal Medicine in Ain Shams University Hospital, Cairo, Egypt. | ||||
| Abstract | ||||
| Systemic lupus erythematosus (SLE) shows various clinical manifestations with various immunological abnormalities. The development of lupus nephritis and vasculitis is common in patients with SLE. As angiotensin I-converting enzyme (ACE) has been reported to be associated with various immunological phenomena, we investigated the correlation between insertion(I) / deletion(D) polymorphism of the ACE gene and SLE. Fifty Egyptian patients with SLE and thirty healthy control persons were involved in this study. ACE gene was detected by the polymerase chain reaction (PCR). In SLE patients, there is a significant difference when comparing DD and II genotypes (P<0.05),being higher in the DD genotype. And a highly significant difference when comparing ID and II genotypes (P=0.001), being much higher in ID genotype than II genotype. According to vasculitis, there is a significant relationship between vasculitis and patients genotypes when comparing ID genotype with both II and DD genotypes (P<0.05), being highest in ID genotype. There is a significant relationship found when comparing ID genotype with both II and DD genotypes, being highest in ID genotype in patients with score ≥21. These results suggest that the ACE genotype could be associated with SLE. | ||||
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