RESIDUES OF FURAZOLIDONE IN RAW AND BOILED EGGS AFTER ITS ADMINISTRATION TO LAYING HENS | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 13, Volume 4, Issue 1, June 1995, Page 84-88 PDF (2.53 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1995.186357 | ||||
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Authors | ||||
Mohamed Khairy 1; Ferial Soliman2; Mostafa Abd El Aziz3; Sawsan El-Sheikh4; Mohamed Ahmed3 | ||||
1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt. | ||||
2Animal Health Research Institute, Dokki, Cairo, Egypt | ||||
3Department. of pharmacology, Faculty of Veterinary Medicine, Zagazig University. | ||||
4Department of Pharmacology, Faculty of Vet. Medicine, Zagazig University | ||||
Abstract | ||||
Furazolidone residue in raw and boiled eggs were measured after administration of the prophylactic dose (20 mg/kg b. wt. for 10 successive days) and the therapeutic dose (35 mg/kg b. wt. for 7 successive days) to laying hens and the clearance time of the drug in the laid eggs was also estimated. The concentration of Furazolidone residue in raw eggs of the prophylactic group was zero in the first day of dosing, in the 2nd day of dosing the concentration was 0.12ug/gm albumin and 0.09 ug/gm yolk and increased gradually to the peak at the 10th day of drug administration (0.41 ug/gm albumin and 0.39 ug/gm yolk. This level declined gradually till reached zero after 6 days in egg albumin and 7 days in the egg yolk from last dosage. Meanwhile, the boiled eggs showed low Furazolidone residues than raw eggs. As far the therapeutic dose groups, Furazolidone residues were detected at the 2nd day of dosing at concentration of 0.18 ug/gm albumin and 0.13 ug/gm yolk and increased to the peak at 7th day (0.50 ug/gm albumin and 0.40 ug/gm yolk) and declined till reached zero after 6 days in the egg albumin and 7 days in egg yolk. In boiled eggs the residues of Furazolidone were lower than in raw eggs. | ||||
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