Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent
Elsabagh, M., Fayez, H., Motaleb, M., Zaghary, W., Sakr, T. (2022). Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent. EKB Journal Management System, 65(2), 249-258. doi: 10.21608/ejchem.2021.85086.4150
Mohammed F. Elsabagh Elsabagh; Hend Fayez; Mohammed A. Motaleb; Wafaa A. Zaghary; Tamer M. Sakr. "Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent". EKB Journal Management System, 65, 2, 2022, 249-258. doi: 10.21608/ejchem.2021.85086.4150
Elsabagh, M., Fayez, H., Motaleb, M., Zaghary, W., Sakr, T. (2022). 'Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent', EKB Journal Management System, 65(2), pp. 249-258. doi: 10.21608/ejchem.2021.85086.4150
Elsabagh, M., Fayez, H., Motaleb, M., Zaghary, W., Sakr, T. Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent. EKB Journal Management System, 2022; 65(2): 249-258. doi: 10.21608/ejchem.2021.85086.4150

Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent

Egyptian Journal of Chemistry
Article 28, Volume 65, Issue 2, February 2022, Page 249-258  XML PDF (547.62 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.85086.4150
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Authors
Mohammed F. Elsabagh Elsabagh email 1; Hend Fayez1; Mohammed A. Motaleb1; Wafaa A. Zaghary2; Tamer M. Sakr3
1Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
3Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.
Abstract
Graphene is a crystalline form of carbon that is regarded as a novel and innovative product. carboxylated nanographene oxide sheets (NGO-COOH) was synthesized using a modified Hummer's method and assess their medical significance. NGO-COOH were successfully synthesized with an average size of 40 nm. FT-IR, UV–Vis, XPS spectrophotometry, and TEM were used to thoroughly describe them. The cytotoxicity function of NGO-COOH nanosheets were tested against cell line. The radiosynthesized [99mTc]Tc-NGO-COOH had a high radiolabeling yield (97.3±0.45 %). The tumor uptake of [99mTc]Tc-NGO-COOH nanosheets in an in vivo biodistribution model in tumor-bearing mice was high. NGO-COOH nanosheets may be a promising imaging agent, based on these findings.
Keywords
Nanographene sheets; Technetium-99m; Nanosynthesis; Tumor imaging; Radiolabeling
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