HEPATOPROTECTIVE AND ANTIOXIDANT ACTION OF WHEY PROTEIN, AND ITS FRACTIONS IN RATS AFTER ACUTE CCL4 EXPOSURE | ||||
Journal of Food and Dairy Sciences | ||||
Article 7, Volume 32, Issue 7, July 2007, Page 5435-5443 PDF (801.37 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jfds.2007.204601 | ||||
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Authors | ||||
Soad H. Taha1; A. M. Abd El-Fattah1; A. A. El-Nimer2; Somaia A. Nada3; Jihan M. Kassem2 | ||||
1Dairy Science and Technology Department, Faculty of Agriculture, Cairo University | ||||
2Dairy Department, National Research Center, Dokki, Giza | ||||
3Pharmacology Department, National Research Center, Dokki, Giza | ||||
Abstract | ||||
Exposure to CCl4 may increase the production of reactive oxygen species, which results in the damage of tissues, especially the liver. The purpose of this study is to evaluate the effects of whey protein (wp), α-lactalbumin(α- la )and β-lactoglobulin (β-lg) (100mg each) on the superoxide dismutase (SOD) status, liver and kidney functions after acute CCl4 exposure in the rats. The results showed that with the feeding on WP, α-la and β-lg, the SOD level displayed a significant increase after acute exposure to CCl4. The parameters of liver functions showed a significant decrease in the transferases (ALT, AST & GGT) and a significant increase in protein synthesis (TP & albumin). The kidney functions parameters (uric acid & createinine) are significantly reduced when WP, α-la and β-lg were administered. These results suggest that WP and its fractions should be a precursor agent to promote the production of SOD that enhance the antioxidant capacity and improve the liver and kidney functions. | ||||
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