The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers
Eldakroury, M., Darwish, A., Darwish, A. (2021). The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers. EKB Journal Management System, 6(2), 25-27. doi: 10.21608/djvs.2021.91626.1045
Mohamed Eldakroury; alshymaa Darwish; Asmaa Darwish. "The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers". EKB Journal Management System, 6, 2, 2021, 25-27. doi: 10.21608/djvs.2021.91626.1045
Eldakroury, M., Darwish, A., Darwish, A. (2021). 'The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers', EKB Journal Management System, 6(2), pp. 25-27. doi: 10.21608/djvs.2021.91626.1045
Eldakroury, M., Darwish, A., Darwish, A. The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers. EKB Journal Management System, 2021; 6(2): 25-27. doi: 10.21608/djvs.2021.91626.1045

The Effect of Clindamycin Oral Administration on Some Immunological and Biochemical Parameters of Newcastle Vaccinated Broilers

Damanhour Journal of Veterinary Sciences
Article 5, Volume 6, Issue 2, September 2021, Page 25-27  XML PDF (158.42 K)
Document Type: Original Article
DOI: 10.21608/djvs.2021.91626.1045
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Authors
Mohamed Eldakrouryorcid 1; alshymaa Darwish2; Asmaa Darwish email orcid 3
1Department of pharmacology, Faculty of Veterinary Medicine, Matrouh University
2Department of biochemistry, Faculty of pharmacy, Sohage University.
3ِِAnimal and poultry health department, desert research center
Abstract
Present work aimed to study some immunological and biochemical effects of Clindamycin on broiler vaccinated against Newcastle virus. Three groups of one day old Hubbard chicks each of 50 birds were used in this study. Group (1) was control non treated group (CG). Group C20 and C40 were given Clindamycin (20mg/kg and 40mg/kg body. wt) respectively in drinking water at 14th, 15th and 16th days of age. All groups were routinely vaccinated against Newcastle virus at 7 and 18 day of age. On 25th day of age, blood samples were collected from ten birds of each group for immunological and biochemical tests. Five birds from each group were slaughtered at the same age then the lymphoid organs (thymus, bursa and spleen) were carefully separated & weighed and each organ relative weight was determined. Number of dead birds were recorded throughout the experiment period (45 day age). It was observed that administration of Clindamycin decreased the leukocytic count haemagglutination inhibition antibody titer (HI), total protein, globulin and the relative weight of bursa in C20 and C40. It did not induce any significant changes in the differential leukocytic count, liver and kidney function tests, spleen relative weight in C20 and C40. While, relative weight of thymus and body weight gain significantly decreased in C40 and non-significantly changed in C20. While, feed conversion rate significantly increased in C40 only. In addition, C20 and C40 had higher mortality rates than CG. Conclusion: Clindamycin administration suppresses the chicken's immune response to Newcastle disease virus vaccine.
Keywords
Newcastle vaccine; immunological parameters; biochemical parameters; broilers
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