Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats
El-sayed, M., Elkomy, A., Farag, E., gad, A. (2021). Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats. EKB Journal Management System, 41(1), 148-153. doi: 10.21608/bvmj.2021.72813.1396
Mosaad El-sayed; Ashraf, A. Elkomy; Enas Farag; aya gad. "Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats". EKB Journal Management System, 41, 1, 2021, 148-153. doi: 10.21608/bvmj.2021.72813.1396
El-sayed, M., Elkomy, A., Farag, E., gad, A. (2021). 'Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats', EKB Journal Management System, 41(1), pp. 148-153. doi: 10.21608/bvmj.2021.72813.1396
El-sayed, M., Elkomy, A., Farag, E., gad, A. Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats. EKB Journal Management System, 2021; 41(1): 148-153. doi: 10.21608/bvmj.2021.72813.1396

Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats

Benha Veterinary Medical Journal
Article 33, Volume 41, Issue 1, October 2021, Page 148-153  XML PDF (986.11 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2021.72813.1396
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Authors
Mosaad El-sayed1; Ashraf, A. Elkomy1; Enas Farag2; aya gad email 1
1Department of Pharmacology, Faculty of Veterinary Medicine, Benha university, Egypt
2Department of pharmacology, Animal Health Research Institute, Benha, Egypt.
Abstract
Albendazole is an abroad spectrum anthelmintic used for treatment of different parasites.Liver toxicity and elevation of liver marker enzymes occur secondary to usage of albendazole(alb) .Organium majorana extract (OME) has a hepatoprotective effect against albendazole (alb) enhanced hepatic toxicity in rats as assayed in the present study.Twenty male rats were divided into four equal groups five rats for each group .Group1: (Normal control), received no drugs, Group 2: (OM-treated), rats received an oral dose of OME (200mg/kg b.wt/day) for 30 successive days .Group 3: (alb treated ) received an oral dose of alb (7.5 mg/kg b.wt.) for 15 successive days .Group 4 (OME protected+ alb ), rats pretreated with OME (200 mg/kg b.wt/day) orally for 30 days before alb treatment for 15 days.Results showed significant (P<0.05) raise in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) ,total protein ,direct bilirubin and decrease of albumin level compared to control group and group treated with OME. Albendazole also induced histopathological alteration in liver tissue. OME showed significant protection against albendazole-induced hepatotoxicity that confirmed through serum biochemical analysis and the histopathological examination of liver tissues and might be beneficial for the hepatotoxicity.
Keywords
Albendazole; Hepatic damage; Organium majorana extract , Hepatoprotection and rats
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