Hepato Effect of Argel Herb (Solenostemma argel) against Carbon Tetra Chloride Induced Liver damage in Albino Rats. | ||||
International Journal of Family Studies, Food Science and Nutrition Health | ||||
Volume 2, Issue 2, December 2021, Page 142-161 PDF (1.51 MB) | ||||
Document Type: Original Research | ||||
DOI: 10.21608/ijfsnh.2021.219932 | ||||
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Authors | ||||
Dalia D. Azer1; Ayman F. Kahlil1; Alshimaa A. Hafez1; Eshak M. El-Hadidy2 | ||||
1Home Economic, Specific Education Faculty, Ain Shams University, Egypt | ||||
2Food Technology Research Institute, Agriculture Research Center, Giza, Egypt | ||||
Abstract | ||||
Argel (Solenostemma argel) is a traditional edible herb that is commonly used in folkloric medicine for the treatment of rheumatic pain, inflammation, hyperlipidaemia, hyperglycaemia and antimicrobial agent due to its rich in bioactive component which act as antioxidants. Forty-eight male albino rats were used in biological experiments. Rats were fed the basal diet for two weeks prior to conducting the experiment. Initially, rats divided into six main groups and fed on rations for 42 days as follows: the negative control group (the first group) was fed on the basal diet. Forty male albino rats were fed on a basic diet and stimulated with carbon tetra chloride (CCl4( in paraffin oil (50% v/v, 2 mL/Kg) twice a week by subcutaneous injection to induce chronic liver damage, then divided into 5 groups numbered from group 2 to group 6. Rats of the positive control group were fed basal diet until the final experiment. Group 3 and 4 rats were treated with dry leaves (0.5g and1.0g, respectively) of Argel. Also, group 5 and 6 were fed on 50 ppm and 100 ppm of hydroethanolic extracts orally, respectively. Biochemical analyses as serum ALT, AST, ALP and MDA were significant decreased in rats fed on dried and extracts in Argel compared to positive group. In Contrast, it could be that SOD activity in rat groups was significant increased compared to positive group. Also, Argel extracts had highest effect for liver parameters than dried Argel. These results are concluded that Argel could be suggested to the hepatoprotective effect of Argel may be due to its antioxidants content and free radical scavenging effect. | ||||
Keywords | ||||
Argel S. argel; Hydroethanolic extracts; Hepatoprotective; Oxidative stress | ||||
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