Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species
Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. (2022). Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species. EKB Journal Management System, 3(2), 420-427. doi: 10.21608/mid.2022.110401.1218
Jaidaa Mekky; Shwikar Ahmad; Mona Metwali; Samar Farouk; Shehab Monir; Ahmed ElSayed; Sara Asser. "Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species". EKB Journal Management System, 3, 2, 2022, 420-427. doi: 10.21608/mid.2022.110401.1218
Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. (2022). 'Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species', EKB Journal Management System, 3(2), pp. 420-427. doi: 10.21608/mid.2022.110401.1218
Mekky, J., Ahmad, S., Metwali, M., Farouk, S., Monir, S., ElSayed, A., Asser, S. Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species. EKB Journal Management System, 2022; 3(2): 420-427. doi: 10.21608/mid.2022.110401.1218

Clinical phenotypes and constipation severity in Parkinson’s disease: Relation to Prevotella species

Microbes and Infectious Diseases
Article 21, Volume 3, Issue 2, May 2022, Page 420-427  XML PDF (429.88 K)
Document Type: Original Article
DOI: 10.21608/mid.2022.110401.1218
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Authors
Jaidaa Mekky1; Shwikar Ahmadorcid 2; Mona Metwali2; Samar Farouk2; Shehab Monir3; Ahmed ElSayed3; Sara Asser email orcid 2
1Department of Neuropsychiatry, Faculty of Medicine, Alexandria University, Egypt
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Alexandria University, Egypt
3Alexandria University Faculty of Medicine, Egypt
Abstract
Background: The gut microbiome is speculated to play a crucial role in its pathogenesis of Parkinson’s disease as a triggering factor. Recent hypotheses suggested that Prevotella species regulate gut permeability, exert a neuroprotective effect, and interestingly, has been suspected to be deficient in PD patients, and so may play a role in this disease. Aim: This study was designed to compare between PD patients and their healthy controls as regards relative Prevotella abundance, prevalence of Prevotella-dominant Enterotype, and constipation severity. Also, to correlate Prevotella changes with the clinical phenotypes and  severity of motor and non-motor symptoms of PD. Methods: Twenty-five PD cases were enrolled in this study and cross-matched to 25 healthy subjects representing the control group. Overall NMS severity was assessed using the Non-Motor Symptoms Scale (NMSS). Quantitative SYBR green Real Time PCR was performed for the identification and quantitation of Prevotella in stool. Results: Prevotella relative abundance was 4-fold decreased in cases when compared to controls with PIGD phenotype showing the lowest abundance, however the difference was not statistically significance. Prevotella-dominant Enterotype was less presented in cases compared to controls, the result was statistically significant. Severe and very severe constipation grades presented 64% of cases group Vs 12% of control group. There was statistically significant positive correlation between total constipation score and UPDRS total score and motor symptoms phenotypes. Conclusion: Relative low Prevotella abundance in PD patients appears to be related to severe phenotypes of the disease; PIGD and mixed phenotypes. Severe constipation was more presented in PD cases which may be considered  as a preclinical biomarker for PD.
Keywords
GUT microbiome; Parkinson's disease; Prevotella
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