Hepatotreatment Effect of Silybum, Spirulina and Propolis Consumption Compared to Silymarin Drug in Experimental Rats | ||||
| Journal of Food and Dairy Sciences | ||||
| Article 3, Volume 13, Issue 1, January 2022, Page 17-24 PDF (1.51 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jfds.2022.120162.1037 | ||||
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| Authors | ||||
M. A. Abd El-Ghany1; Rasha M. Nagib1; Hanan A. Hashem  2
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| 1Faculty of Specific Education, Home Economics Dept., Mansoura University –Egypt. | ||||
| 2Faculty of Specific Education, Mansoura University –Egypt. | ||||
| Abstract | ||||
| The purpose of this study was to investigate whether Silybum, Spirulina, and Propolis may have a therapeutic impact when compared to the silymarin medication. .The results revealed that,Negative control showed significant lower in weight gain, feed efficiency ratio,serum HDL-c, total protein, albumin, globulin, catalase(CAT),superoxide dismutase (SOD) and Cytochrome P450(CYP450) and significant higher in serum liver enzyme (ALT,AST,ALP, γ GT),total bilirubin ,creatinine, urea ,uric acid,cholesterol,triglycerides,LDL-c, VLDL-c and cholesterol /HDLc, ,LDLc/HDLc and malondialdehyde (MDA) compared to negative control. Administration of Silymarin, Silybum, Spirulina Propolis and mixture of them to liver injured rats for both the treated or preventive group showed a significant decrease in serum liver enzyme (ALT,AST,ALP, γ GT),total bilirubin ,creatinine ,urea ,uric acid, cholesterol, triglycerides, LDL-c, VLDL-c and cholesterol /HDLc, ,LDLc/HDLc and (MDA) and significant increase in weight gain, feed efficiency ratio, HDL-c, total protein, albumin,globulin,CAT,SOD,andCYP450 in compared to positive control.Histopathological examination revealed that consumption of Silymarin, Silybum, Spirulina Propolis can lower pathological changes in injured.It can be recommended that consumption of Silymarin, Silybum, Spirulina Propolis and mixed them could manage treat liver injury rat by improve liver and renal function, lipids profiles ,antioxidant enzymes and Cytochrome P450. | ||||
| Keywords | ||||
| Silymarin; Silybum; Spirulina Propolis Nutritional; liver; CCL4; rat | ||||
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