Association of Hepatitis C viral load with liver functions and risk factors among HCV patients, Minia governorate, Egypt | ||||
| Novel Research in Microbiology Journal | ||||
| Volume 5, Issue 1, January and February 2021, Page 1118-1131 PDF (586.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/nrmj.2021.149386 | ||||
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| Authors | ||||
Hala R. Ahmed1; Reham A. Ibrahem   1; Rehab M. Abd El-Baky 2; Helal F. Hetta3; Amr M. Elsayed4; Nancy G. F. M. Waly1
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| 1Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt | ||||
| 2Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, 11566, Egypt | ||||
| 3Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| 4Department of Tropical medicine and Gastroenterology, Faculty of Medicine, Minia University, Minia, Egypt | ||||
| Abstract | ||||
| Hepatitis C virus (HCV) is one of the blood transmitted hepatitis viruses. HCV infections have been identified as major causes of chronic hepatic diseases, and hepatocellular carcinoma. The aims of the current study were to determine the HCV viral load between 35 hepatitis C patients in Minia governorate, Egypt, and to assess association of the viral load with abnormal liver functions including; Alanine aminotransferase (ALT), prothrombin activity and platelet count. In addition to assessing if there are any risk factors associated with the population group, sex, age and other factors. About 35 blood samples were collected from hepatitis C patients randomly selected from the outpatient clinic at the Viral Hepatitis Management Center, Minia governorate, Egypt; including males and females of different ages. Viral load was determined using Real-time polymerase chain reaction (RT-PCR). All relevant information was collected from each patient including personal and clinical data. Current results showed that 68.60 % of the samples were from males and 31.4 % were from females, and most of them aged between 51 and 70 years. Approximately 11 (31.4 %) of the HCV patients had viral loads of <106, 12 (34.3 %) recorded viral loads of <105, and about 12 cases (34.3 %) had a viral load of < 104. HCV infection has been associated with 4 risk factors representing high HCV transmission routes including; dental intervention (80.0 %), history of hospital admission (65.7 %), previous surgeries (57.1 %) and family history of HCV (48.6 %). However, history of Schistosomiasis and blood-transfusion showed low association with HCV infection; recording (31.4 %) and (22.9 %), respectively. | ||||
| Keywords | ||||
| Hepatitis; HCV; Liver functions; RT-PCR; Risk factors | ||||
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