THE HEPATOPROTECTIVE AND ANTI-FIBROTIC ACTIVITIES OF FREEZE-DRIED SAPONIN AND TANNIN EXTRACTS ON CCI4 - INDUCED HEPATOTOXICITY IN RATS. | ||||
| Journal of Food and Dairy Sciences | ||||
| Article 3, Volume 30, Issue 9, September 2005, Page 5407-5418 PDF (146.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jfds.2005.237931 | ||||
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| Authors | ||||
| O. A . Shaban,1; Somaya M. Moursy2; Amal M. H. Abdel- Haleem2 | ||||
| 1Faculty of Agric., Cairo Univ . | ||||
| 2Crops Technology Research Oep., Food Technology Res. Institute | ||||
| Abstract | ||||
| Saponins ot defatted soybean seeds and tannins of faba bean hulls were extracted. freeze-dried and the chemical composition was determined before and after extraction and freeze-drying. The hepatoprotective and anti-fibrotic activities of these freeze-dried extracts on carbon tetrachloride (CCI4)-induced hepatotoxicity on rats were evaluated. Repeated administration of CCI. subcutaneously (S.C) on rats for 8 weeks significantly elevated serum enzymes activity assessted tor liver function, i.e .. AST, AL T and ALP. Also, the same administration accumulated and deposited the hepatic collagen protein of rats. The altered chemical parameters and the accumulated and deposited collagen were significantly benefited by tne both fTeeze-dned extracts administration per ora::y (P.O). The results show that both freeze-dried saponin and tannin extracts have a hepatoprotective and anti-fibrotic activities against CCI~. induced hepatotoxicity in rats. but the mechanism and the active compounds of these extracts require further studies. | ||||
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