EFFECT OF SELENIUM NANOPARTICLES AND/OR spirulina platensis ON GROWTH, HEMATOBIOCHEMICAL, ANTIOXIDANT STATUS, HORMONAL PROFILE, IMMUNITY, AND APOPTOSIS OF GROWING RABBITS EXPOSED TO THERMAL STRESS | ||||
| Egyptian Journal of Rabbit Science | ||||
| Volume 32, Issue 1, January 2022, Page 77-103 PDF (780.92 K) | ||||
| Document Type: Original Article | ||||
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| Authors | ||||
Amr Bashar; Sameh Abd el nour; Abdelhalim El-Darawany; Asmaa Sheiha 
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| Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. | ||||
| Abstract | ||||
| This research was conducted to reconnoiter the influence of dietary supplementation of Spirulina platensis (SP) or/and selenium nanoparticles (SeNPs) on the growth, blood metabolites and antioxidants capacity of heat-stressed rabbits. Rabbits (n = 120) were divided into 4 experimental groups as the following: the 1st group fed basal diet without supplementation and sarved as a control (CON). The 2nd group fed basal supplemented with 1 gm/kg diet of SP (SP), the 3rd group fed basal diet supplemented with 50 mg/kg diet SeNPs (SeNPs) and 4th group fed basal diet supplemented with 1 gm/kg diet of SP (SP) plus50 mg/kg diet SeNPs (SeNPs) . Dietary inclusion with SeNPs and SP significantly (P < 0.05) improved all growth indices in heat stressed rabbits. Circulating hemoglobin, platelets, total protein, albumin and globulins were significantly improved in SeNPs and SP+SeNPs groups compared with CON group; however, WBCs were significantly decreased in all treated groups. Significant reduction in ALT, total bilirubin, direct bilirubin, total glycerides, creatinine, and uric acids were observed in treated groups compared with the CON group. All experimental additives significantly improved the levels of IgG relative to CON group (P<0.001). Dietary feed inclusion resulted in lower levels of oxidative stress (MDA and PCO; P < 0.001), while all treatments showed significant enhancement in the level of GSH. The mixture of SP+SeNPs had higher level of T3 (P＜0.001), while both SP and SP+SeNPs treatments had lower values of plasma corticosterone (P＜0.001). The morphologic of caspase3 immune expression of heat stressed rabbits presented moderate of intracytoplasmic immunoreactivity that existing by a substantial rise in part ratio of caspase 3 immunoreactivity related to another group. Conclusively, the present results manifest that SeNPs and/or SP can be possibly to mitigate the negative influences of heat stressed rabbit by enhancing the antioxidant, immunological and reducing the apoptosis process. | ||||
| Keywords | ||||
| Heat stress; rabbit; growth indices; blood metabolites; antioxidant; apoptosis | ||||
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