Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.
Shaltout, E., Makboul, R., Abdellah, N., Ebrahem, N. (2022). Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.. EKB Journal Management System, 22(2), 127-137. doi: 10.21608/ejfsat.2021.78014.1202
Eman Shaltout; Rania Makboul; Nora Abdellah; Noha Ebrahem. "Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.". EKB Journal Management System, 22, 2, 2022, 127-137. doi: 10.21608/ejfsat.2021.78014.1202
Shaltout, E., Makboul, R., Abdellah, N., Ebrahem, N. (2022). 'Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.', EKB Journal Management System, 22(2), pp. 127-137. doi: 10.21608/ejfsat.2021.78014.1202
Shaltout, E., Makboul, R., Abdellah, N., Ebrahem, N. Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.. EKB Journal Management System, 2022; 22(2): 127-137. doi: 10.21608/ejfsat.2021.78014.1202

Possible Multi-Organ Toxicity in Rats after Chronic Oral Administration of Titanium Dioxide: Biochemical and Histopathological Study.

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 22, Issue 2, June 2022, Page 127-137  XML PDF (795.61 K)
Document Type: Original Article
DOI: 10.21608/ejfsat.2021.78014.1202
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Authors
Eman Shaltoutorcid 1; Rania Makboulorcid 2; Nora Abdellah email orcid 3; Noha Ebrahemorcid 4
1Department of Forensic Medicine and clinical toxicology Faulty of Medicine, Assiut University,Egypt
2Pathology Department, Faculty of Medicine, Assiut University, Egypt
3Department of Forensic Medicine and clinical toxicology Faulty of Medicine, Assiut University, Egypt
4Lecturer of Forensic Medicine and Clinical Toxicology, Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Assiut University, Egypt
Abstract
Titanium dioxide (TiO2) is used abundantly as a white pigment with many applications; food coloring agents, additives, tooth whitening paste, pharmaceutical preparations, painting materials, and sunscreen creams. Objectives: The present study aimed to explore the possible toxicological effects of orally administered TiO2. Methodology: Twenty male albino rats were given food-grade TiO2 in a dose of 20 mg/kg BW via oral gavage at 1 mL daily volume for 120 consecutive days. 20 male rats were used as a control group. Liver enzymes (AST, ALT, and ALP), renal function (urea and creatinine), creatine kinase activity (CK-MB isoenzyme), and serum levels of troponin were measured at the end of the study for each rat. Histopathological analysis of cardiac, hepatic, renal, and gastrointestinal tissue sections was also performed for both groups. Results: Increased CK-MB, cardiac Troponin, ALT, ALP, and urea serum levels in TiO2 treated groups were recorded. Histopathological examination showed focal fibrosis of cardiac tissue. Hepatic sections showed inflammation and fat deposits. Gastrointestinal wall inflammations with blunting of the villi all over the small intestine, active inflammation of the colon and kidney tissues in the renal pelvis were found. Conclusion: Prolonged daily oral administration of food-grade TiO2 can induce cardiovascular, hepatic, intestinal, and renal adverse effects.
Keywords
Titanium dioxide; Organ toxicity; Food Additives
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