Mechanisms of Cyclosporin A Induced Hepatotoxicity

Faheem, Safaa Ahmed; Moustafa, Yasser M.; El- Sayed, Norhan M.; hazem, reem; Saeed, Noha M.

doi:10.21608/rpbs.2022.129863.1133

	Mechanisms of Cyclosporin A Induced Hepatotoxicity
Records of Pharmaceutical and Biomedical Sciences
Article 5, Volume 6, Issue 1, April 2022, Page 57-68 PDF (804.25 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2022.129863.1133
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Authors
Safaa Ahmed Faheem ¹; Yasser M. Moustafa ²; Norhan M. El- Sayed ²; reem hazem³; Noha M. Saeed⁴
¹Department of pharmacology and toxicology, Faculty of pharmacy, Egyptian Russian University
²Pharmacology and Toxicology department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
³Department of pharmacology and toxicology ,faculty of pharmacy ,Suez Canal University ,Ismailia,Egypt
⁴Pharmacology and Toxicology department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt
Abstract
Cyclosporin A (CsA); an immunosuppressive agent, is broadly used for the remedy of autoimmune diseases and after organ transplantations. However, its medical and experimental use is restrained with the aid of quite few side effects, such as nephrotoxicity, cardiotoxicity, hypertension and hepatotoxicity. Despite its toxicity, CsA remains to be one of the most usually used immunosuppressive agent due to its therapeutic efficacy. The key mechanisms involved in organ damage caused by CsA include altered redox homeostasis and chronic systemic inflammation. Indeed, various mechanisms have been suggested for CsA induced hepatotoxicity along with the development of reactive oxygen species, oxidative stress, and hepatic antioxidant system depletion. In some of the side findings, many mechanisms concerned have been appreciably explored and explained. Nevertheless, the mechanisms underlying CsA-mediated hepatotoxicity are not utterly understood. This review discusses CsA toxicity and its pathophysiology and role of oxidative stress in the initiation of the toxicity in addition to the different Therapeutic approaches for its toxicity.
Keywords
CsA; Oxidative stress; hepatotoxicity; nephrotoxicity; inflammation


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