Traditional, One pot Three Component Synthesis and Anti-Bacterial Evaluations of Some New Pyrazoline Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 22, Volume 65, Issue 10, October 2022, Page 239-248 PDF (1.1 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.129819.5727 | ||||
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| Authors | ||||
Soran Omed Mamand  1; Dalia Abdul2; farouq Hawaiz3
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| 1Department of Chemistry, College of Science, University of Sulaimani, Kurdistan Region, Iraq | ||||
| 2Department of Chemistry, University of Sulaimani, College of science, Iraq -Kurdistan Region | ||||
| 3Department of Chemistry, College of Education, Salahaddin University-Hawler, Erbil-Kurdistan, Iraq | ||||
| Abstract | ||||
| In this work synthesized a new series of pyrazoline compounds containing azo linkages via classical and one pot three component reactions. The progress started with 3-chloro,4-methyl aniline which has been diazotized and coupled with 4-hydroxy acetophenone to form azo compound 1-(3-((3-chloro-4-methylphenyl) diazenyl)-4-hydroxyphenyl) ethan-1-one (1) and converted to 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl) diazenyl) phenyl) ethan-1-one (2). The later azo compound subjected to both classical and one pot method to give target pyrazoline derivatives. The structure of all new obtained compounds were supported by spectral data (1H-NMR, 13CNMR, Dept.135, and FT-IR). Finally, some pyrazoline derivatives were estimated for their anti-bacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive. The results showed significant activity against both types of bacteria. | ||||
| Keywords | ||||
| Bis-benzyloxy; One-pot synthesis; Pyrazoline; Anti-Bacterial activity; Claisen- Schmidt condensation | ||||
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