Assessment of Serum Level of C1q/TNF Related-Protein Isoform 15 in Psoriatic Patients | ||||
| Benha Journal of Applied Sciences | ||||
| Article 13, Volume 7, Issue 4, April 2022, Page 103-106 PDF (410.01 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2022.254552 | ||||
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| Authors | ||||
| Y.Y. AbdElsamie1; S.E. Ibrahim1; I.A. Elsayed2; E.M.E. Akl1 | ||||
| 1Dermatology, Venereology and Andrology , Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| 2Medical Biochemistry and Molecular Biology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| Abstract | ||||
| Background: Psoriasis is a chronic inflammatory skin disease, affecting 1.5–3% of the world population. The pathogenesis of psoriasis is complex and depends on many factors, including genetic, neurogenic, hormonal and autoimmune. The present study aims to evaluate serum C1q/TNF‐related protein isoform 15 (CTRP15) level in psoriatic patients. This case control study included 80 subjects divided into 2 groups Group A included 50 patients suffering from generalized plaque psoriasis and Group B included 30 apparently healthy individuals of matched age and sex were chosen as a control group. All subjects were selected from the Outpatient Clinic of Dermatology and Andrology at Benha University Hospital from October 2020 to April 2021. Patients were told to stop using topical therapy for 2 weeks or systemic therapy for 4 weeks before the study. Psoriasis was diagnosed clinically and confirmed by dermoscopic examination and curttage test. All the patients were subjected to full history taking, complete clinical examination, and laboratory investigations as Fasting blood glucose, Lipid profile (TC,TG,HDL and LDL). Results & Conclusion: The present study showed that the mean age of psoriasis group was 46.3 years, they were 32 males (64%) and 18 females (36%). In addition to 30 healthy control group of matched age and gender (p>0.05 for each). no significant differences were found between studied groups regarding blood pressure. The present work found that patients had significantly higher BMI and WC when compared to control group and positive family history of psoriasis | ||||
| Keywords | ||||
| C1q; TNF; Related-Protein Isoform; Psoriasis | ||||
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