HISTOPATHOLOGICAL CHANGES IN HEART AND LUNG OF ALBINO RAT TREATED WITH MACHETE HERBICIDE | ||||
| Journal of Plant Protection and Pathology | ||||
| Article 6, Volume 27, Issue 10, October 2002, Page 7043-7052 PDF (2.88 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jppp.2002.255354 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Fatma K. Khidr | ||||
| Plant Protection Res. Institute, Agric. Res. Center, Dokki-Giza, Egypt | ||||
| Abstract | ||||
| The present study aims to illustrate the histopathological effect of 1/4 LD50 oral administration of herbicide Machete on heart and lung of albino rats at intervals 1, 2, 3, 4 and 5 weeks post-treatment. Significant decrease in body weight were recorded, while a significant increase were recorded in heart and lung weight comparing with control. Also, significant decrease in the number of erythrocytes, leucocytes, haemoglobin level, haematocrit value and packed cell volume were observed. Concerning the histopathological changes in heart, there was oedema, inflammatory cells infiltration in the subendocardial tissue and the myocardial blood vessels were hyperemic, while changes in lung, there was lymphoid cells aggregation with hyperemic blood vessels in association with the presence of alveolar emphysema in diffuse manner. Perivascular lymphoid cells aggregation and peribronchiolar lymphoid hyperplasia were observed. | ||||
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