GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.)
Abdel-Hak, M., Abdel-Mogib, M., Mostafa, M., Abd El-Moneim, M., Yousef Mostafa, A. (2023). GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.). EKB Journal Management System, 4(1), 1-12. doi: 10.21608/ajbas.2022.152453.1117
Marwa Rabee Abdel-Hak; Mamdouh Abdel-Mogib; Mohamed E. Mostafa; Mohamed Abd El-Moneim; Amal M. Yousef Mostafa. "GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.)". EKB Journal Management System, 4, 1, 2023, 1-12. doi: 10.21608/ajbas.2022.152453.1117
Abdel-Hak, M., Abdel-Mogib, M., Mostafa, M., Abd El-Moneim, M., Yousef Mostafa, A. (2023). 'GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.)', EKB Journal Management System, 4(1), pp. 1-12. doi: 10.21608/ajbas.2022.152453.1117
Abdel-Hak, M., Abdel-Mogib, M., Mostafa, M., Abd El-Moneim, M., Yousef Mostafa, A. GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.). EKB Journal Management System, 2023; 4(1): 1-12. doi: 10.21608/ajbas.2022.152453.1117

GC/MS Volatile Constituents Analysis and Anticancer Activity of Moltkiopsis ciliata (Forssk.)

Alfarama Journal of Basic & Applied Sciences
Article 1, Volume 4, Issue 1, January 2023, Page 1-12  XML PDF (572.92 K)
Document Type: Original Article
DOI: 10.21608/ajbas.2022.152453.1117
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Authors
Marwa Rabee Abdel-Hak email orcid 1; Mamdouh Abdel-Mogib2; Mohamed E. Mostafa3; Mohamed Abd El-Moneim4; Amal M. Yousef Mostafaorcid 5
1chemistry department,faculty of science,port said university
2chemistry department,faculty of science, mansoura university, mansoura,egypt
3plant protection research institute,agriculture research center,12618,Egypt
4Chemistry Department, Faculty of Science, Port Said Univeristy, Egypt.
5Chemistry department,faculty of science,port said university,port said ,egypt
Abstract
Methanolic extract of the aerial part of Moltkiopsis ciliata (Forssk.) (Boraginaceae) was obtained and successively fractionated into two main fractions (hexane fraction and methylene chloride fraction), which were phytochemically investigated using GC/MS technique. The whole of thirty-five compounds were identified and quantified. They are belonging to different classes; twenty-one acetogenins (Fat derivatives), six shikimates, five terpenes and one sterol. Beside the characterization of the volatile compounds profile, β-amyrin was isolated and identified using chromatographic and spectral techniques. The methanolic extract and two fractions were screened for their cytotoxic activity against breast cancer cell line MCF7 and hepatocellular carcinoma cell line HepG2. The methylene chloride fraction was proved to be the most potent cytotoxic agent. The major phyto-components of the two fractions were known by their various biological activity as antimicrobial, antiprofilative, antioxidant, Hypocholesterolemic, Antiandrogenic flavor, Nematicide, pesticides, anti-inflammatory, Hemolytic and have significant pharmaceutical importance especially as anticancer agents. The bioactive volatile constituents recommended phytopharmaceutical importance of the plant
Keywords
Moltkiopsis ciliata; Boraginaceae; GC/MS technique; volatile constituents; cytotoxic activity
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