Immuno-enhancement of barely β-glucan or barley extracts on arsenic trioxide-induced immunosuppressed rat model | ||||
| International Journal of Family Studies, Food Science and Nutrition Health | ||||
| Volume 3, Issue 2, December 2022, Page 1-39 PDF (985.24 K) | ||||
| Document Type: Original Research | ||||
| DOI: 10.21608/ijfsnh.2022.259041 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Hanaa Sayed Mohamed Abd El-Rahman | ||||
| Special Food and Nutrition Dept., Food Technology Research Institute, Agric. Res. Center, Giza, Egypt | ||||
| Abstract | ||||
| The present investigation aimed to study the biological effects of barely βglucan or barley extracts on arsenic trioxide-induced immunosuppression. Fiftyfour male albino rats (weighing 100±25 g) were divided into eight groups, each group including six rats. Group 1: PBS was injected intraperitoneally into the rats, while saline was given orally (negative control). Groups 2–8 received daily intraperitoneal injections of As2O3 (5 mg/kg) for 4 weeks. Group 2 serves as a positive control. The rats in groups 3, 4, and 5 were received daily doses of βglucan extracts of 40, 80, and 160 mg/kg bw/day, respectively, with ATO (arsenic trioxide). Groups 6, 7, and 8 were given barley extract at doses of 0.7, 1.4, and 2.8 g/kg bw/day, respectively, with ATO. At the end of the experiment, all of the rats were slaughtered for biochemical, hematological, and histopathological analysis. The obtained results revealed that barley β-glucan and barley extracts increased CAT and GPx activity while lowering MDA levels in the spleen tissue of rats. | ||||
| Keywords | ||||
| barely β-glucan; barley; immunity; Arsenic trioxide; inflammation | ||||
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