Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats
Khallaf, H., Aboubakr, M., said, A. (2023). Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats. EKB Journal Management System, 43(2), 6-9. doi: 10.21608/bvmj.2022.175583.1611
Hoda Mahmoud Khallaf; Mohamed Hafez Aboubakr; alshaimaa Mohammed said. "Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats". EKB Journal Management System, 43, 2, 2023, 6-9. doi: 10.21608/bvmj.2022.175583.1611
Khallaf, H., Aboubakr, M., said, A. (2023). 'Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats', EKB Journal Management System, 43(2), pp. 6-9. doi: 10.21608/bvmj.2022.175583.1611
Khallaf, H., Aboubakr, M., said, A. Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats. EKB Journal Management System, 2023; 43(2): 6-9. doi: 10.21608/bvmj.2022.175583.1611

Impact of Colistin-Induced Nephrotoxicity on Renal Oxidant/Antioxidant Status in Male Rats

Benha Veterinary Medical Journal
Volume 43, Issue 2, January 2023, Page 6-9  XML PDF (960.66 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2022.175583.1611
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Authors
Hoda Mahmoud Khallaf1; Mohamed Hafez Aboubakr2; alshaimaa Mohammed said email orcid 1
1Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University
2Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt
Abstract
Colistin, a glycopeptide antibiotic, is only used as an emergency treatment in case of multidrug-resistant bacterial infections. Due to its propensity for causing nephrotoxicity, colistin has a limited range of applications. In this study, the effect of colistin administration on kidney functions and oxidant/antioxidant status were investigated in rats. Twenty-four male rats were divided randomly into three equal groups. Control group; Colistin 7 group: received 300,000 IU colistin intraperitoneally twice daily for 7 days; Colistin 14 group: received 300,000 IU colistin twice daily for 14 days. The obtained results demonstrated a significant increase in serum urea, creatinine, uric acid, and renal Malondialdehyde (MDA) concentrations with marked decrease in serum albumin, renal glutathione (GSH) concentrations, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in both colistin-administered groups when compared to the control. Additionally, colistin administered for 14 days exhibited significant alterations in the biochemical parameters compared to colistin 7 days administered rats group. In conclusion, colistin alters the renal oxidant/antioxidant status and elevates kidney function tests that are deteriorated by a long treatment period.
Keywords
Colistin; Nephrotoxicity; Oxidative stress; Biochemical; Antioxidant
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