Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats
Gamal, A., AboSalem, M., El-Shewy, E., medhate hegazy, A., saber, S. (2023). Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats. EKB Journal Management System, 43(2), 19-24. doi: 10.21608/bvmj.2022.176212.1613
Aya Gamal; Mohamed AboSalem; Elham El-Shewy; ahmed medhate hegazy; samar saber. "Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats". EKB Journal Management System, 43, 2, 2023, 19-24. doi: 10.21608/bvmj.2022.176212.1613
Gamal, A., AboSalem, M., El-Shewy, E., medhate hegazy, A., saber, S. (2023). 'Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats', EKB Journal Management System, 43(2), pp. 19-24. doi: 10.21608/bvmj.2022.176212.1613
Gamal, A., AboSalem, M., El-Shewy, E., medhate hegazy, A., saber, S. Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats. EKB Journal Management System, 2023; 43(2): 19-24. doi: 10.21608/bvmj.2022.176212.1613

Coenzyme Q10 supplementation alleviates the oxidative stress on the liver imposed by mercuric chloride in albino rats

Benha Veterinary Medical Journal
Volume 43, Issue 2, January 2023, Page 19-24  XML PDF (1019.08 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2022.176212.1613
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Authors
Aya Gamal email 1; Mohamed AboSalem2; Elham El-Shewy3; ahmed medhate hegazy4; samar saberorcid 5
1forensic medicine and toxicology, veterinary medicine, benha university,Qalyubia,egypt
2forensic medicine and toxicology, veterinary medicine,benha university,Qalyubia,Egypt
3Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Benha University
4forensic medicine and toxicology,veterinary medicine,benha univerisity,menofia,egypt
5forensic medicine and toxicology, faculaty of veterinary medicine , benha university, Qalybia, Egypt
Abstract
Mercury is given particular attention, because of its ability for detrimental impacts on both human and animal health. Therefore it is, claimed that it accumulates in the liver, causing liver toxicity, and tissue damage. Consequently, it was intended for the current research to explore the potential antioxidant activity of CoQ10 against HgCL2-induced hepatotoxicity. Twenty-eight male albino rats were split into four groups: the control group, given saline; the CoQ10 group, given coenzyme Q10 (10mg/kg bwt); the HgCL2 group, given mercuric chloride (1mg/kg bwt); and the co-treated group, given coenzyme Q10 group+HgCL2 group (10mg/kg bwt , 1mg/kg bwt respectively). All treatments were received orally for 4 weeks. The HgCL2 group had significantly higher serum concentrations of the enzymes alanine aminotransferase (ALT); aspartate aminotransferase (AST); alkaline phosphatase (ALP)and lactate dehydrogenase (LDH), While total protein and albumin were significantly decreased. The Rats also showed a significant increase in mercury concentration and exhibited a notable spike of lipid peroxidation levels with concurrent declines in antioxidant enzymes (GSH), also our result was confirmed by histopathological examination of liver tissues. Treatment with CoQ10 produces protection against hepatotoxicity caused by HgCL2.CoQ10 mitigates biochemical parameters, histopathological changes, and mercury buildup in liver tissues. In conclusion, CoQ10 could be the best choice to counteract the oxidative damage produced by mercury exposure.
Keywords
HgCL2; Oxidative stress; Mercuric residues; Coenzyme -Q10
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