Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies
Rady, M., Okdah, Y., Hassaan, H., Nofal, A. (2023). Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies. EKB Journal Management System, 66(10), 377-387. doi: 10.21608/ejchem.2023.175461.7203
Mohamed Rady; Yosry Okdah; Hamada Hassaan; AMANY EBRAHIM Nofal. "Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies". EKB Journal Management System, 66, 10, 2023, 377-387. doi: 10.21608/ejchem.2023.175461.7203
Rady, M., Okdah, Y., Hassaan, H., Nofal, A. (2023). 'Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies', EKB Journal Management System, 66(10), pp. 377-387. doi: 10.21608/ejchem.2023.175461.7203
Rady, M., Okdah, Y., Hassaan, H., Nofal, A. Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies. EKB Journal Management System, 2023; 66(10): 377-387. doi: 10.21608/ejchem.2023.175461.7203

Hepatoprotective Effect of Gum Arabic Versus Cisplatin Hepatotoxicity in Adult Male Rats: Biochemical, Histological and Ultrastructural Studies

Egyptian Journal of Chemistry
Volume 66, Issue 10, October 2023, Page 377-387  XML PDF (4.12 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.175461.7203
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Authors
Mohamed Radyorcid 1; Yosry Okdahorcid 2; Hamada Hassaan3; AMANY EBRAHIM Nofal email orcid 4
1Professor of Cytochemistry and Histochemistry Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
2Professor of Histology and Histochemistry, Zoology Department, Faculty of Science, Menoufia University, 32511, Shebang El- Kom, Egypt.
3Zoology Department, Faculty of Science,Menoufia University,Shebin El-kom, Egypt.
4Dept. of Zoology, Faculty of Science, Menoufia University
Abstract
Hepatotoxicity is an imperative drawback of treatment with antineoplastic Cisplatin (Cis). Gum Arabic (GA) is a drained Gummy dislodged from the Acacia Senegal branches and stems, composed of calcium, potassium, and magnesium salts of polysaccharide GA acid. The objective of the current study is to evaluate the capability of GA to keep liver save safe from damage caused by a single intraperitoneal weekly dose of 7.5 mg Cis/kg rats. Twenty-four albino rats were located randomly in 4 groups; G1 act as control, G2 received GA, G3 received Cis, and G4 received simultaneously both Cis and GA. The results showed that Cisplatin-induced elevation in liver enzymes and caused different histological lesions in the hepatic structures. Immunohistochemically moderate positive reactions for PCNA and Caspase-3 were detected in hepatocytes of Cis in comparison with control. While, GA as a protective antioxidant exhibited a significant improvement in biochemical, histological, and immunohistochemical parameters, suggesting the use of GA in combination with Cis to attenuate liver damage in cancer patients.
Keywords
Cisplatin; Electron microscope; Immunohistochemistry; liver; PCNA
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