Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome
Abo-Elaala, N., Mohamed, A., Mayez, M., Ahmed, K., Abd-Almajid, W., Abd El-Megied, M. (2023). Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome. EKB Journal Management System, 61(1), 138-167. doi: 10.21608/bnni.2023.298595
Nebal A Abo-Elaala; Ahmed G Mohamed; Mohamed M Mayez; Karema A Ahmed; Walid M Abd-Almajid; Mohammed A Abd El-Megied. "Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome". EKB Journal Management System, 61, 1, 2023, 138-167. doi: 10.21608/bnni.2023.298595
Abo-Elaala, N., Mohamed, A., Mayez, M., Ahmed, K., Abd-Almajid, W., Abd El-Megied, M. (2023). 'Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome', EKB Journal Management System, 61(1), pp. 138-167. doi: 10.21608/bnni.2023.298595
Abo-Elaala, N., Mohamed, A., Mayez, M., Ahmed, K., Abd-Almajid, W., Abd El-Megied, M. Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome. EKB Journal Management System, 2023; 61(1): 138-167. doi: 10.21608/bnni.2023.298595

Review: Correlation between Type 1 Diabetes Mellitus and Gut Microbiome

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt
Volume 61, Issue 1, June 2023, Page 138-167  XML PDF (545.32 K)
Document Type: Original Article
DOI: 10.21608/bnni.2023.298595
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Authors
Nebal A Abo-Elaala1; Ahmed G Mohamed2; Mohamed M Mayez2; Karema A Ahmed2; Walid M Abd-Almajid2; Mohammed A Abd El-Megied* 3
1Department of Clinical Nutrition, National Nutrition Institute NNI, Cairo, Egypt.
2Ministry of Health and Population, Cairo, Egypt
3Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt
Abstract
Diabetes mellitus (DM) is one of the most common metabolic disorders all over the world. Type 1 diabetes (T1D) is a subtype of DM that is characterized by autoimmunity and B-cell destruction. T1D is considered a disease of multifactorial origin with genetic susceptibility and environmental factors. The environmental (triggering) factors are numerous and including gut microbiome (GM). GM is a humorous dynamic population of microbes that harbor the intestine and have a marked effect on our metabolic diseases and homeostasis. Many studies found that dysbiosis and compositional changes in GM play important roles in T1D development. The objective of this study was to determine the correlation between T1D and GM to establish the best strategies for microbiome alteration to assist in the prevention of T1D occurrence and for better glycaemic control in the near future. The search studies address the question of the relationship between T1D and GM. All available data provided by PubMed/MEDLINE, Google Scholar, Springer Link, EM base Medline, and Cochrane Library were reviewed to fulfill the required objectives. Conclusion: Diet can alter the onset and course of autoimmune disorders including T1D by modifying the gut microbiome.
Keywords
Diabetes mellitus; T1D; Gut microbiome
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