Nanoparticles Photosensitization in Sebaceous Gland | ||||
| The International Conference on Mathematics and Engineering Physics | ||||
| Article 17, Volume 4, International Conference on Mathematics and Engineering Physics (ICMEP-4), May 2008, Page 1-15 PDF (512.72 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/icmep.2008.29895 | ||||
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| Authors | ||||
| Mohamed M Hashem; Farouk. I. Hammouda; Soheir S. Korraa | ||||
| Abstract | ||||
| Aِbstract Aim of Study: Current topical and most oral therapies for sebaceous glands have limited efficacy because drugs active constituents do not reach the sebaceous gland efficiently. Most recently it has been shown laser-induced flow in nanoscale cavities could represent a successful mechanism low level laser therapy. Aim of the work: The aim of the present study is to investigate, whether a coordinate combination betweeen laser therapy and methylene blue delivered by liposomes or gel can be effective in destructing sebaceous glands Materials and Methods: Gel or liposome preparations of Methylene blue were topically applied on mice skin. After being absorbed into skin methylene blue was exposed to different fluencies of He:Ne laser and skin biopsies were obtained and examined histiologically. Results: Liposome delivery system showed significantly increased diffusion of methylene blue into the pilosebaceous unit and deeper skin layers compared to gel delivered methylene blue. It was evident that destruction of the pilosebaceous unit depends on laser parameters and the on lag time between laser application and biopsy sampling. Conclusion: Temporal coordination between low level laser treatment and liposome delivered methylene blue drug system maximizes drug effects and minimizes possible adverse effects. Irradiation should start when the drug concentration has reached its maximum in the desired field of action | ||||
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