Biochemical effect of cranberry extract on experimentally induced myocardial infarction
Ali, H., Mahmoud, O., Hussein, M., Mohammed, M. (2017). Biochemical effect of cranberry extract on experimentally induced myocardial infarction. EKB Journal Management System, 32(1), 59-66. doi: 10.21608/bvmj.2017.31113
Hussien A. Ali; Omnia A. Mahmoud; Mohammed A. Hussein; Mariam S. Mohammed. "Biochemical effect of cranberry extract on experimentally induced myocardial infarction". EKB Journal Management System, 32, 1, 2017, 59-66. doi: 10.21608/bvmj.2017.31113
Ali, H., Mahmoud, O., Hussein, M., Mohammed, M. (2017). 'Biochemical effect of cranberry extract on experimentally induced myocardial infarction', EKB Journal Management System, 32(1), pp. 59-66. doi: 10.21608/bvmj.2017.31113
Ali, H., Mahmoud, O., Hussein, M., Mohammed, M. Biochemical effect of cranberry extract on experimentally induced myocardial infarction. EKB Journal Management System, 2017; 32(1): 59-66. doi: 10.21608/bvmj.2017.31113

Biochemical effect of cranberry extract on experimentally induced myocardial infarction

Benha Veterinary Medical Journal
Article 10, Volume 32, Issue 1, March 2017, Page 59-66  XML PDF (280.69 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2017.31113
View on SCiNiTO View on SCiNiTO
Authors
Hussien A. Ali1; Omnia A. Mahmoud1; Mohammed A. Hussein2; Mariam S. Mohammed2
1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University
2Department of Biochemistry, Faculty of Pharmacy, October 6 University
Abstract
Myocardial infarction (MI) is characterized by an inequity of coronary blood supply and demand, which results in
myocardial ischemic injury and damages the cardiomyocytes. Isoproterenol (ISO) is a synthetic catecholamine cause
toxicity leading to severe stress in the myocardium of experimental animals. The aim of the present article is to investigate
cardioprotective activity of cranberry extract against ISO-induced cardiotoxicity in adult rats. Oral administration of
cranberry extract at a concentration of 75 and 150 mg/kg b.wt. daily for 28 days showed a significant protection againstinduced
alteration in plasma total cholesterol (TC), triacyclglycerols (TG), high density lipoprotein (HDL-C), low density
lipoprotein (LDL-C), tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) as well as cardiac superoxide dismutase
(SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), catalase (CAT) levels. In addition, cranberry extract
reduced plasma Creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) as
well as cardiac thiobarbituric acid reactive substances (TBARS) levels (MDA) as compared to control group. In
conclusion, cranberry extract renders resiliency against isoproterenol cardiotoxicity due to its antioxidant and free radical
scavenging activity
Keywords
Cranberry extract; Isoproterenol; myocardial infarction; antioxidant
Statistics
Article View: 132
PDF Download: 258