Novel Indene-[1,3,4]Oxadiazine hybrids: Design, construction, molecular docking, QSAR, ADME study and anticancer potential | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 2, February 2024, Page 497-512 PDF (840.12 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.216875.8133 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Modather F Hussein   1; Ibrahim Althobaiti2; Hamud Altaleb3; Yasser abubaker4; Azzah Elenazi4; Nadia Ali Ahmed5; Rania Bakr6
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| 1Modather F. hussein Chemistry Department, Collage of Science, Jouf University | ||||
| 22Department of Chemistry, College of Science and Arts, Jouf University, Quryat, 42421, Saudi Arabia | ||||
| 33Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia | ||||
| 4Chemistry Department, Collage of Science, Jouf University | ||||
| 5Chemistry Department, College of Science, Jouf University, Sakaka , 2014, Saudi Arabia. Chemistry Department, Faculty of Science, Aswan University, Aswan, 81528, Egypt | ||||
| 64Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt | ||||
| Abstract | ||||
| In an attempt to improve and develop biologically potential anticancer agents, synthesis of new anticancer agents are in progress. This study focused on the synthesis of novel compounds and examined the anticancer potentials of lung cancer cell line (A549), breast cancer cell line (MCF-7) and liver cancer cell line (HepG2) using MTT assay. Molecular docking and ADME studies were performed for the anticancer compounds. A novel set of indeno[2,1-e][1,3,4]oxadiazinone 2a-f was designed and constructed via a reaction of ninhydrin, hydrazine hydrate and the appropriate isothiocyanate. The anticancer impact of the newly prepared compounds 2a-f was assessed in vitro against A549, MCF-7 and HepG2 cell lines. The cyclohexylmethylaminoindenooxadiazinone derivative 2f was the most active candidate towards A549 and HepG2 with IC50 (64.88 and 39.18 µg/ml), respectively. A molecular docking study was done within EGFR active site to predict the binding mode of the novel compounds. Both compounds 2b and 2f recorded high binding energy scores with the excellent fitting with the active site. ADME study results displayed compounds 2b and 2f registered positive values showing good drug-likeness behavior. Multiple linear regression analysis was used to construct consistent QSAR models based on quantum mechanics-derived chemical descriptors. The experimental anticancer activity data correlated well with the expected one. Hence, it is possible to speculate that the novel compound 2f could be considered n anticancer lead compound. | ||||
| Keywords | ||||
| indenooxadiazinones; anticancer; cytotoxic potential; docking study; drug-likeness | ||||
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