Efficacy of inactivated BEF vaccine adjuvant with Montanide ISA 206 compared with the locally prepared inactivated BEF vaccines | ||||
| Benha Veterinary Medical Journal | ||||
| Article 15, Volume 31, Issue 2, December 2016, Page 117-123 PDF (348.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2016.31278 | ||||
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| Authors | ||||
| El-Bagoury G. F.1; El-Habbaa A. S.1; Amal A. M.2; Nermeen G. S.2 | ||||
| 1Department of Virology, Faculty of Veterinary Medicine, Benha University | ||||
| 2Central Laboratory for Evaluation of Veterinary Biologics, Abbassia, Cairo | ||||
| Abstract | ||||
| Bovine ephemeral fever (BEF) virus belonging to Ephemerovirus genus of the Rhabdoviridae family causes an economically important seasonal acute vector- borne disease. Routine vaccination, is one of the main controlling steps, particularly in countries where the disease is endemic. This study deal with comparative evaluation of humeral immune response of cattle using SNT and ELISA to three inactivated BEF vaccines. Inactivated BEF vaccine with Montanide ISA 206 (water-in-oil-in-water) adjuvant given in 2 doses one month apart gave high protective antibody titer lasted for 44 weeks’ post vaccination (WPV). The inactivated BEF vaccine with aluminum hydroxide gel adjuvant given in 2 doses one month apart gave satisfactory immune response lasted for 30 WPV then neutralizing antibodies waned rapidly. Live attenuated BEF vaccine that inactivated by saponin on time of vaccination give higher antibody titer which rise more rapidly lasted for 38 WPV only. It could be concluding that the inactivated BEF vaccine with Montanide ISA 206 adjuvant gave satisfactory higher and longer lasting antibody titer for 44 WPV and it was recommended to use this vaccine in endemic and non-endemic countries to control and prevent the disease especially before summer season | ||||
| Keywords | ||||
| BEF virus; vaccine; Adjuvant; SNT; ELISA | ||||
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