The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis
Fararh, K., Farid, A., Azzam, I., Sultan, A. (2016). The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis. EKB Journal Management System, 31(2), 149-157. doi: 10.21608/bvmj.2016.31284
Khaled M. Fararh; Ayman Samir Farid; Ibtisam Mohammed Azzam; Asmaa Abdelmonsef Sultan. "The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis". EKB Journal Management System, 31, 2, 2016, 149-157. doi: 10.21608/bvmj.2016.31284
Fararh, K., Farid, A., Azzam, I., Sultan, A. (2016). 'The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis', EKB Journal Management System, 31(2), pp. 149-157. doi: 10.21608/bvmj.2016.31284
Fararh, K., Farid, A., Azzam, I., Sultan, A. The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis. EKB Journal Management System, 2016; 31(2): 149-157. doi: 10.21608/bvmj.2016.31284

The hepato- protective Effect of Stem Cells and Levamisole against Carbontetrachloride induced Liver Fibrosis

Benha Veterinary Medical Journal
Article 20, Volume 31, Issue 2, December 2016, Page 149-157  XML PDF (692.39 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2016.31284
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Authors
Khaled M. Fararh1; Ayman Samir Faridorcid 1; Ibtisam Mohammed Azzam2; Asmaa Abdelmonsef Sultan2
1Clinical Pathology department, Faculty of Veterinary Medicine, Benha University
2Pathology department, Animal Health Research Institute
Abstract
This study designed to evaluate the hepatoprotective effect of stem cells only or stem cells and levamisole on
experimentally Carbon tetrachloride (CCl4) induced liver damage by evaluation of haematological parameters,
biochemical parameters, immunological parameters and histopathological findings. Sixty (60) Wister rats were
divided into four groups with 15 animals in each group. Group (1): normal group. Group (2): rats injected with
CCL4 (0.2ml/100gm) s/c twice a week for 9 weeks. Group (3): rats injected with CCL4 then given MSCs
(3x106 cell) I/v once a week for 4 weeks. Group (4): rats injected with CCL4 then given levamisole (2.5mg/kg)
three successive days for 4 weeks and stem cells (MSCs) (3x106 cell) I/v once a week for 4 weeks. Results
showed that injection of CCL4 lead to significant increase in activity of hepatic enzymes (AST, ALT, ALP)
and Bilirubin level while it decreased serum total protein, albumin, IL- 6, Phagocytic index, Phagocytic %,
IgG and IgM. While after treatment with stem cells only or stem cells and levamisole lead to significant
decrease in activity of hepatic enzymes (AST, ALT, ALP) and Bilirubin level while it increased serum total
protein, albumin, IL- 6, Phagocytic index, Phagocytic %, IgG and IgM
Keywords
Liver fibrosis; Carbon tetrachloride; Levamisole and Mesenchymal Stem Cells
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